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Guanabenz hydrochloride

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Purity:99.59%

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COA LCMS HNMR

Guanabenz hydrochloride

Catalog No. T21957Cas No. 23113-43-1

Guanabenz hydrochloride (NE56490) is an orally active α2-adrenoceptor agonist with hypotensive effects.

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Pack Size	Price	Availability
25 mg	$33	In Stock
50 mg	$64	In Stock
100 mg	$122	In Stock
500 mg	$297	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

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Product Introduction

Bioactivity

Description	Guanabenz hydrochloride (NE56490) is an orally active α2-adrenoceptor agonist with hypotensive effects.
In vivo	Maximum concentrations of guanabenz hydrochloride in plasma (1.2 to 5.2 ng/ml) reached 2 to 5 hours after administration of capsules containing 16 or 32 mg of 14C-labelled guanabenz hydrochloride. Guanabenz hydrochloride was 90% bound to human plasma proteins. Guanabenz hydrochloride competed for imidazoline I2-binding sites in brown adipose tissue with Ki of 97 nM.
Alias	NE56490

Chemical Properties

Molecular Weight	267.54
Formula	C8H9Cl3N4
Cas No.	23113-43-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/ml (205.58 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7378 mL	18.6888 mL	37.3776 mL	186.8879 mL
5 mM	0.7476 mL	3.7378 mL	7.4755 mL	37.3776 mL
10 mM	0.3738 mL	1.8689 mL	3.7378 mL	18.6888 mL
20 mM	0.1869 mL	0.9344 mL	1.8689 mL	9.3444 mL
50 mM	0.0748 mL	0.3738 mL	0.7476 mL	3.7378 mL
100 mM	0.0374 mL	0.1869 mL	0.3738 mL	1.8689 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc