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Hepln-13

Catalog No. T25492 CAS 64369-13-7

Synonyms: Hepln 13, Hepln13

Hepln-13 is a hepsin inhibitor that acts by hindering prostate cancer bone metastasis.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Hepln-13, CAS 64369-13-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 54.00
5 mg	In stock	$ 128.00
10 mg	In stock	$ 213.00
25 mg	In stock	$ 428.00
50 mg	In stock	$ 639.00
100 mg	In stock	$ 890.00
500 mg	In stock	$ 1,830.00
1 mL * 10 mM (in DMSO)	In stock	$ 147.00

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Purity: 99.83%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Hepln-13 is a hepsin inhibitor that acts by hindering prostate cancer bone metastasis.
Targets&IC50	Hepsin:0.33 μM
In vitro	Hepln-13 (10 μM; 2 hours; 293 cells) inhibits cleavage[1].
In vivo	HepIn-13 displays dose-dependent inhibition of Hepsin overexpression-relevant prostate cancer phenotypes in LPB-Tag/PB-Hepsin mice and blocks prostate cancer metastasis in this animal model.

Synonyms	Hepln 13, Hepln13
Molecular Weight	325.2
Formula	C17H13BrN2
CAS No.	64369-13-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (184.50 mM), Sonification is recommended.

References and Literature

1. Tang X, et al. Targeted inhibition of cell-surface serine protease Hepsin blocks prostate cancer bone metastasis. Oncotarget. 2014;5(5):1352-1362.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Inhibitor Library Anti-Cancer Active Compound Library Tyrosine Kinase Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Colorectal Cancer Compound Library Anti-Liver Cancer Compound Library Orally Active Compound Library Anti-Lung Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Hepln-13 64369-13-7 Tyrosine Kinase/Adaptors c-Met/HGFR potent non-toxic overexpression-relevant phenotypes orally inhibit Hepln 13 prostate cancer Inhibitor Hepln13 inhibitor

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