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IAXO-102

Catalog No. T11598   CAS 1115270-63-7

IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development.

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IAXO-102 Chemical Structure
IAXO-102, CAS 1115270-63-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 89.00
2 mg In stock $ 136.00
5 mg In stock $ 263.00
10 mg In stock $ 422.00
25 mg In stock $ 689.00
50 mg In stock $ 981.00
100 mg In stock $ 1,350.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development.
In vitro IAXO-102 (10 μM, for 17 hours) suppresses LPS induced pro-inflammatory proteins MCP-1 and IL-8 production in HUVEC. IAXO-102 (1-10 μM, for 2 hours) inhibits MAPK and p65 NF-κB phosphorylation in human umbilical vein endothelial (HUVEC) cells.
In vivo IAXO-102 (3 mg/kg/day, s.c. for 28 days) significantly retards Angiotensin II-induced increase in aortic diameter in mice.
Molecular Weight 585.94
Formula C35H71NO5
CAS No. 1115270-63-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 45 mg/mL (76.8 mM), sonification is recommended.

DMSO: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Huggins C, et al. A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development. Atherosclerosis. 2015 Oct;242(2):563-70.

Related compound libraries

This product is contained In the following compound libraries:
Clinical Compound Library Inhibitor Library Immuno-Oncology Compound Library Drug Repurposing Compound Library Immunology/Inflammation Compound Library Bioactive Compound Library NO PAINS Compound Library Pyroptosis Compound Library Bioactive Compounds Library Max

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Vesatolimod CU-CPT-9a TLR7 agonist 1 CL264 Schaftoside Chloroquine Chloranil Isofraxidin

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Keywords

IAXO-102 1115270-63-7 Immunology/Inflammation TLR IAXO 102 Toll-like Receptor (TLR) Inhibitor IAXO102 inhibit inhibitor

 

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