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IC261

Catalog No. T2440   CAS 186611-52-9
Synonyms: SU-5607

IC261 (SU-5607) is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM.

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IC261 Chemical Structure
IC261, CAS 186611-52-9
Pack Size Availability Price/USD Quantity
5 mg In stock $ 64.00
10 mg In stock $ 98.00
25 mg In stock $ 189.00
50 mg In stock $ 289.00
100 mg In stock $ 428.00
500 mg In stock $ 969.00
1 mL * 10 mM (in DMSO) In stock $ 70.00
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Purity: 99.86%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description IC261 (SU-5607) is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM.
Targets&IC50 CK1:16 μM, CDK5:4.5 mM.
In vitro IC261 leads to a p53-dependent arrest of the cells with a DNA content of 4 N. It can produce effects on cell cycle progression that are indistinguishable from an established spindle poison and are dependent on the p53 status of the cells[1].
In vivo Intrathecal injection of a CK1 inhibitor IC261 attenuates neuropathic pain behaviors. CK1 inhibitors are found to be effective in reducing spinal excitatory response elicited by the presynaptic electrical stimulation only in neuropathic mice[2]. Targeting CK1 isoforms by IC261 influences both pancreatic tumour cell growth and apoptosis sensitivity in vitro and the growth of induced tumours in vivo[3].
Cell Research Cultures of MEFs of di?erent genotypes (p53+/+, p53+/7, p537/7) are treated with the inhibitor IC261 in the low micromolar range (1 μM). After 12, 24, 48 hours exposure, the effects of IC261 on cell cycle distribution are measured by flow cytometry.(Only for Reference)
Synonyms SU-5607
Molecular Weight 311.33
Formula C18H17NO4
CAS No. 186611-52-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 58 mg/mL (186.3 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Behrend L, et al. Oncogene. 2000, 19(47):5303-5313. 2. Sakurai E, et al. Mol Pain. 2009, 5:74. 3. Brockschmidt C, et al. Gut. 2008, 57(6):799-806. 4. Liu F, et al. Proc Natl Acad Sci U S A. 2001, 98(20):11062-11068.

Related compound libraries

This product is contained In the following compound libraries:
Stem Cell Differentiation Compound Library Covalent Inhibitor Library Inhibitor Library Kinase Inhibitor Library Apoptosis Compound Library Anti-Aging Compound Library Wnt/Hedgehog/Notch Compound Library Anti-Breast Cancer Compound Library Metabolism Compound Library Cell Cycle Compound Library

Related Products

Related compounds with same targets
PF-562271 hydrochloride KenPaullone CDK8-IN-4 Trilaciclib hydrochloride CLK1-IN-1 ALSTERPAULLONE CDK4/6-IN-2 CDK8/19-IN-1

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Keywords

IC261 186611-52-9 Apoptosis Cell Cycle/Checkpoint Metabolism Stem Cells Casein Kinase CDK Inhibitor inhibit IC-261 SU 5607 SU5607 IC 261 SU-5607 inhibitor

 

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