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ICA-121431

Catalog No. T7336 CAS 313254-51-2

Synonyms: 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl

ICA-121431 is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, with little or no activity against human Nav1.5 or Nav1.7 channels.

ICA-121431, CAS 313254-51-2

Pack Size	Availability	Price/USD
2 mg	In stock	50.00
5 mg	In stock	72.00
10 mg	In stock	101.00
25 mg	In stock	176.00
50 mg	In stock	295.00
100 mg	In stock	443.00
1 mL * 10 mM (in DMSO)	In stock	82.00

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Purity 98.00%

HNMR COA Datasheet MSDS

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ICA-121431 is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, with little or no activity against human Nav1.5 or Nav1.7 channels.
Targets&IC50	Nav1.7 :ic50 19 nM,

Synonyms	2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl
Purity	98.00%
Molecular Weight	449.55
Formula	C23H19N3O3S2
CAS No.	313254-51-2

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 44 mg/mL (97.88 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Song G , Yang D , Wang Y , et al. Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators[J]. Nature, 2017. 2. Mccormack K , Santos S , Chapman M L , et al. Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels[J]. Proceedings of the National Academy of Sciences, 2013, 110(29):E2724-E2732.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.