Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ilomastat (GM6001) (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
2 mg | In stock | $ 59.00 | |
5 mg | In stock | $ 96.00 | |
10 mg | In stock | $ 156.00 | |
25 mg | In stock | $ 283.00 | |
50 mg | In stock | $ 477.00 | |
100 mg | In stock | $ 688.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 101.00 |
Description | Ilomastat (GM6001) (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor. |
Targets&IC50 | MMP-1:0.4 nM(Ki), MMP-2:0.5 nM(Ki), MMP-26:0.36 nM(Ki), MMP-9:0.2 nM(Ki), MMP-8:0.1 nM(Ki) |
In vivo | Topical application of GM6001 (400 μg/ml) prevents corneal ulceration after severe alkali injury. [3] In rabbit model after stenting, GM6001 significantly inhibits intimal hyperplasia and intimalcollagen content, and it increases lumen area in stented arteries without effects on proliferation rates. [4] |
Kinase Assay | Collagenase assay uses the synthetic thiol ester substrate Ac-Pro-Leu-Gly-SCH(i-Bu)CO-Leu-Gly-OEt at pH 6.5. The collagenase concentration is 1-2 nM, and the substrate concentrations are from 0.1 to 0.7 nM. Km?is found to vary between 1.5 and 4 mM. |
Synonyms | Galardin, GM6001 |
Molecular Weight | 388.46 |
Formula | C20H28N4O4 |
CAS No. | 142880-36-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 38.9 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Ilomastat 142880-36-2 Proteases/Proteasome MMP Galardin GM-6001 GM 6001 inhibit Matrix metalloproteinases Inhibitor GM6001 inhibitor