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Ilomastat

Catalog No. T2743   CAS 142880-36-2
Synonyms: Galardin, GM6001

Ilomastat (GM6001) (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor.

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Ilomastat Chemical Structure
Ilomastat, CAS 142880-36-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 41.00
2 mg In stock $ 59.00
5 mg In stock $ 96.00
10 mg In stock $ 156.00
25 mg In stock $ 283.00
50 mg In stock $ 477.00
100 mg In stock $ 688.00
1 mL * 10 mM (in DMSO) In stock $ 101.00
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Purity: 99.56%
Purity: 99.51%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ilomastat (GM6001) (GM6001, Galardin) is a broad spectrum matrix metalloprotease (MMP) inhibitor.
Targets&IC50 MMP-1:0.4 nM(Ki), MMP-2:0.5 nM(Ki), MMP-26:0.36 nM(Ki), MMP-9:0.2 nM(Ki), MMP-8:0.1 nM(Ki)
In vivo Topical application of GM6001 (400 μg/ml) prevents corneal ulceration after severe alkali injury. [3] In rabbit model after stenting, GM6001 significantly inhibits intimal hyperplasia and intimalcollagen content, and it increases lumen area in stented arteries without effects on proliferation rates. [4]
Kinase Assay Collagenase assay uses the synthetic thiol ester substrate Ac-Pro-Leu-Gly-SCH(i-Bu)CO-Leu-Gly-OEt at pH 6.5. The collagenase concentration is 1-2 nM, and the substrate concentrations are from 0.1 to 0.7 nM. Km?is found to vary between 1.5 and 4 mM.
Synonyms Galardin, GM6001
Molecular Weight 388.46
Formula C20H28N4O4
CAS No. 142880-36-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 38.9 mg/mL (100 mM)

TargetMolReferences and Literature

1. Grobelny D, et al. Biochemistry, 1992, 31(31), 7152-714. 2. Leppert D, et al. J Immunol,1995, 154(9), 4379-4389. 3. Schultz GS, et al. Invest Ophthalmol Vis Sci, 1992, 33(12) 3325-3331. 4. Li C, et al. J Am Coll Cardiol, 2002, 39(11), 1852-1858. 5. Luan F, Yu Z, Yin L, et al. Accurate detection of matrix metalloproteinase-2 activity in clinical gastric cancer tissues using a fluorescent probe[J]. Analytical Methods. 2019, 11(11): 1516-1521. 6. Xia J, Sun S, Wu X, et al. Enzyme-activated anchoring of peptide probes onto plasma membranes for selectively lighting up target cells[J]. Analyst. 2020 7. Xia J, Sun S, Wu X, et al. Enzyme-activated anchorage of peptide probes on plasma membrane for selectively lighting up target cells. Analyst. 2020 8. Yin L, Sun H, Zhao M, et al. Rational Design and Synthesis of a Metalloproteinase-Activatable Probe for Dual-Modality Imaging of Metastatic Lymph Nodes in Vivo[J]. The Journal of organic chemistry. 2019 May 17;84(10):6126-6133. 9. Yin L, Sun H, Zhang H, et al. Quantitatively Visualizing Tumor-related Protease Activity In Vivo Using A Ratiometric Photoacoustic Probe[J]. Journal of the American Chemical Society. 2019 Feb 20;141(7):3265-3273.

TargetMolCitations

1. Sun Y, Lyu B, Yang C, et al. An enzyme-responsive and transformable PD-L1 blocking peptide-photosensitizer conjugate enables efficient photothermal immunotherapy for breast cancer. Bioactive Materials. 2023, 22: 47-59. 2. Yin L, Sun H, Zhang H, et al. Quantitatively Visualizing Tumor-related Protease Activity In Vivo Using A Ratiometric Photoacoustic Probe. Journal of the American Chemical Society. 2019 Feb 20;141(7):3265-3273. 3. Yin L, Sun H, Zhao M, et al. Rational Design and Synthesis of a Metalloproteinase-Activatable Probe for Dual-Modality Imaging of Metastatic Lymph Nodes in Vivo. The Journal of Organic Chemistry. 2019 May 17;84(10):6126-6133 4. Xia J, Sun S, Wu X, et al. Enzyme-activated anchoring of peptide probes on plasma membrane for selectively lighting up target cells. Analyst. 2020 5. Luan F, Yu Z, Yin L, et al. Accurate detection of matrix metalloproteinase-2 activity in clinical gastric cancer tissues using a fluorescent probe. Analytical Methods. 2019, 11(11): 1516-1521 6. Cheng Z, Jin Y, Li J, et al.Fibronectin-targeting and metalloproteinase-activatable smart imaging probe for fluorescence imaging and image-guided surgery of breast cancer.Journal of Nanobiotechnology.2023, 21(1): 1-16.

Related compound libraries

This product is contained In the following compound libraries:
Preclinical Compound Library Angiogenesis related Compound Library NO PAINS Compound Library Anti-Aging Compound Library Bioactive Compound Library Anti-Metabolism Disease Compound Library Anti-Pancreatic Cancer Compound Library Anti-Cardiovascular Disease Compound Library Bioactive Compounds Library Max Protease Inhibitor Library

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Keywords

Ilomastat 142880-36-2 Proteases/Proteasome MMP Galardin GM-6001 GM 6001 inhibit Matrix metalloproteinases Inhibitor GM6001 inhibitor

 

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