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Indirubin

Catalog No. T6169 CAS 479-41-4

Synonyms: Indigopurpurin, Indigo red, NSC 105327, Couroupitine B

Indirubin (Couroupitine B) is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 uM and 0.6 uM.

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Indirubin, CAS 479-41-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 45.00
10 mg	In stock	$ 61.00
25 mg	In stock	$ 101.00
50 mg	In stock	$ 166.00
100 mg	In stock	$ 288.00
200 mg	In stock	$ 374.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 97.86%

Purity: 96.46%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Indirubin (Couroupitine B) is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 uM and 0.6 uM.
Targets&IC50	Cyclin-dependent kinase:5 μM, GSK-3β:0.6 μM
In vitro	Indirubin is the active ingredient of Danggui Longhui Wan, a mixture of plants that is used in traditional Chinese medicine to treat chronic diseases. Indirubin inhibits CDKs activity with IC50 of 2.2 - 10 μM resulting in cell cycle arrest in the G2/M phase. [1] Indirubin also inhibits GSK-3β with an IC50 of 0.6 μM, attenuating CDK5- and GSK-3β-mediated tau phosphorylation, a process over-active in Alzheimer disease states. [2] It also suppresses tumor necrosis factor (TNF)-induced NF-κB activation in a dose- and time-dependent manner. Indirubin also suppresses the NF-κB activation induced by various inflammatory agents and carcinogens. Indirubin blocks the phosphorylation and degradation of IκBα through the inhibition of activation of IκBα kinase and phosphorylation and nuclear translocation of p65. [3]

Synonyms	Indigopurpurin, Indigo red, NSC 105327, Couroupitine B
Molecular Weight	262.26
Formula	C16H10N2O2
CAS No.	479-41-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 53 mg/mL (202.08 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Hoessel R, et al. Nat Cell Biol, 1999, 1(1), 60-67. 2. Leclerc S, et al. J Biol Chem, 2001, 276(1), 251-260. 3. Sethi G, et al. J Biol Chem, 2006, 281(33), 23425-2335.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library FDA-Approved Kinase Inhibitor Library Inhibitor Library Kinase Inhibitor Library Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Traditional Chinese Medicine Monomer Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library

Related Products

Related compounds with same targets

Cardanol (C15:1) Aristolactam I Rilmenidine hemifumarate Pantoprazole Bornyl acetate Hydroxyurea TJ08 Pyridinium bisretinoid A2E TFA

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Indirubin 479-41-4 Apoptosis Cell Cycle/Checkpoint MAPK PI3K/Akt/mTOR signaling Stem Cells Raf GSK-3 CDK Indigopurpurin Indigo red Inhibitor NSC 105327 inhibit NSC-105327 Couroupitine B anticancer NSC105327 inhibitor

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