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Inz-1

Catalog No. T27617 CAS 897776-15-7

Inz-1 is an effective and fungal-selective inhibitor of mitochondrial cytochrome bc1 with IC50s of 8.092 and 45.320 μM for yeast and human. Inz-1 reverses Fluconazole or other triazole antifungals’ resistance in the pathogenic fungus Candida albicans.

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Inz-1, CAS 897776-15-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 77.00
5 mg	In stock	$ 158.00
10 mg	In stock	$ 266.00
25 mg	In stock	$ 478.00
50 mg	In stock	$ 698.00
100 mg	In stock	$ 995.00
1 mL * 10 mM (in DMSO)	In stock	$ 171.00

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Purity: 99.89%

Purity: 98.57%

Biological Description

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Description	Inz-1 is an effective and fungal-selective inhibitor of mitochondrial cytochrome bc1 with IC50s of 8.092 and 45.320 μM for yeast and human. Inz-1 reverses Fluconazole or other triazole antifungals’ resistance in the pathogenic fungus Candida albicans.
Targets&IC50	Cytochrome bc1 (mitochondrial):45.320 μM(human), Cytochrome bc1 (mitochondrial):8.092 μM(yeast)
In vitro	Inz-1 against Candida and HepG2 respiring growth with IC50 values of 1.655 uM and >32 μM, respectively. Inz-1 (0-16 μM; 24 hours) inhibits the growth of the model yeast S. cerevisiae (strain BY4741) and C. albicans (SC5314) in media containing glucose or glycerol as the sole carbon source, while only mildly slowing growth in glucose. Inz-1 (0-100 μM; 24 hours) shows inhibition of yeast cytochrome B enzymatic activity in a concentration -dependent manner in both wild-type and F90Y mutant mitochondria. It exhibits inhibition of cytochrome bc1 from both S. cerevisiae and C. albicans with IC50 value of 2.5 μM and 8.0 μM, respectively. Inz-1 (0-100 μM; 24 hours) inhibits proliferation under forced respiration conditions only at 32 μM and only mildly at that concentration[1].

Molecular Weight	266.29
Formula	C16H14N2O2
CAS No.	897776-15-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (168.99 mM)

References and Literature

1. Benjamin M Vincent, et al. A Fungal-Selective Cytochrome Bc 1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance.Cell Chem Biol. 2016 Aug 18;23(8):978-991.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Metabolism Disease Compound Library Anti-Cancer Compound Library Bioactive Compound Library Metabolism Compound Library Mitochondria-Targeted Compound Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Inz-1 897776-15-7 Metabolism P450 Inz 1 Fungal inhibit yeast Fluconazole antifungal Candida albicans drug-resistance Cytochrome P450 Inhibitor cell CYPs Cytochrome Bc 1 Inz1 inhibitor

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