Powder: -20°C for 3 years
In solvent: -80°C for 2 years
lonomycin calcium is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. also induces the activation of protein kinase C (PKC). Ionomycin calcium is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin promotes apoptosis.
Description | lonomycin calcium is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. also induces the activation of protein kinase C (PKC). Ionomycin calcium is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin promotes apoptosis. |
In vitro | Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca2+ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells as supported by simultaneously positive fluorescein labeling and propidium iodide uptake. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment. |
Synonyms | Ca2+ channels, PKC, ionophore, Calcium Channel, Ionomycin, SQ 23377, Ionomycin calcium, Antibiotic, Bacterial, SQ23377 calcium, Ca channels, Apoptosis, exosome, inhibit, SQ23377, Inhibitor, cleavage, Protein kinase C, calcium, SQ-23377 |
Molecular Weight | 749.08 |
Formula | C41H72CaO9 |
CAS No. | 56092-82-1 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 9 mg/mL (12.05 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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