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Ionomycin calcium

Catalog No. T11665 CAS 56092-82-1

Synonyms: SQ23377 calcium

lonomycin calcium is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. also induces the activation of protein kinase C (PKC). Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca<Mg<Sr=Ba). Ionomycin promotes apoptosis.

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Ionomycin calcium, CAS 56092-82-1

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1 mg	In stock	$ 127.00
25 mg	4-6 weeks	Inquiry
50 mg	4-6 weeks	Inquiry

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Purity: 98.11%

Biological Description

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Storage & Solubility Information

Description

In vitro

Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca2+ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells as supported by simultaneously positive fluorescein labeling and propidium iodide uptake. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment.

Synonyms	SQ23377 calcium
Molecular Weight	747.07
Formula	C41H70CaO9
CAS No.	56092-82-1

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9 mg/mL (12.05 mM)

References and Literature

1. Liu C,et al. Characterization of ionomycin as a calcium ionophore. J Biol Chem. 1978 Sep 10;253(17):5892-4. 2. Chatila T, et al. Mechanisms of T cell activation by the calcium ionophore ionomycin. J Immunol. 1989 Aug 15;143(4):1283-9. 3. Gil-Parrado S, et al. Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members. J Biol Chem. 2002 Jul 26;277(30):27217-26.

Citations

1. Chen X C, Tang G X, Luo W H, et al. Monitoring and Modulating mtDNA G-Quadruplex Dynamics Reveal Its Close Relationship to Cell Glycolysis. Journal of the American Chemical Society. 2021

Related compound libraries

This product is contained In the following compound libraries：

Microbial Natural Product Library Covalent Inhibitor Library

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Keywords

Ionomycin calcium 56092-82-1 Apoptosis Chromatin/Epigenetic Cytoskeletal Signaling Membrane transporter/Ion channel Metabolism Microbiology/Virology Calcium Channel Antibacterial PKC Antibiotic Ca2+ channels ionophore Ionomycin SQ 23377 SQ23377 calcium Bacterial Ca channels exosome inhibit SQ23377 Inhibitor cleavage Protein kinase C calcium SQ-23377 inhibitor

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