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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $155 | In Stock | |
5 mg | $328 | In Stock | |
10 mg | $563 | In Stock | |
25 mg | $879 | In Stock | |
50 mg | $1,190 | In Stock | |
100 mg | $1,620 | In Stock | |
1 mL x 10 mM (in DMSO) | $333 | In Stock |
Description | Iptacopan hydrochloride (LNP023 hydrochloride) is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. Iptacopan hydrochloride shows direct, reversible, and high-affinity binding to human factor B with a KD of 7.9 nM. |
In vitro | LNP023 demonstrates excellent selectivity over other proteases affording IC50 values of >30 μM across a panel of 41 human proteases, including the AP protein factor D (>100 μM)[3]. |
In vivo | LNP023 (20-180 mg/kg; oral administration) is effective upon prophylactic and therapeutic dosing in an experimental model of membranous nephropathy in rats and prevents KRN (150 μL)-induced arthritis in mice[2]. After oral administration (rat 30 and, dog 10 mg/kg), LNP023 exhibits moderate half-lives (T1/2; Wistar Han rats 3.4 h, beagle dogs 5.5 h) and Cmax (Wistar Han rats 410 nM, beagle dogs 2200 nM)[3]. |
Alias | Iptacopan HCl, LNP023 hydrochloride |
Molecular Weight | 458.98 |
Formula | C25H31ClN2O4 |
Cas No. | 1646321-63-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 50 mg/mL (108.94 mM) DMSO: 50 mg/mL (108.94 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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