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Isoborneol

Catalog No. T7983 CAS 124-76-5

Synonyms: DL-Isoborneol

Isoborneol (DL-Isoborneol) is a monoterpene alcohol, with neuroprotective and antiviral activities

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Isoborneol, CAS 124-76-5

Pack Size	Availability	Price/USD	Quantity
500 mg	In stock	$ 39.00
1 mL * 10 mM (in DMSO)	In stock	$ 29.00

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Purity: 98%

Biological Description

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Description	Isoborneol (DL-Isoborneol) is a monoterpene alcohol, with neuroprotective and antiviral activities
In vitro	Isoborneol, a monoterpene and a component of several plant essential oils, showed dual viricidal activity against herpes simplex virus 1 (HSV-1).?First, it inactivated HSV-1 by almost 4 log10 values within 30 min of exposure, and second, isoborneol at a concentration of 0.06% completely inhibited viral replication, without affecting viral adsorption.?Isoborneol did not exhibit significant cytotoxicity at concentrations ranging between 0.016% and 0.08% when tested against human and monkey cell lines.?Isoborneol specifically inhibited glycosylation of viral polypeptides based on the following data:?(1) the mature fully glycosylated forms of two viral glycoproteins gB and gD were not detected when the virus was replicated in the presence of isoborneol, (2) no major changes were observed in the glycosylation pattern of cellular polypeptides between untreated and isoborneol treated Vero cells, (3) isoborneol did not affect the glycosylation of gB produced from a copy of the gB gene resident in the cellular genome, and (4) other monoterpenes such as 1,8-cineole and borneol,?a stereoisomer of isoborneol, did not inhibit HSV-1 glycosylation[1].
Source	Natural Products > Asteraceae > Blumea

Synonyms	DL-Isoborneol
Molecular Weight	154.25
Formula	C10H18O
CAS No.	124-76-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9 mg/mL (58.35 mM)

References and Literature

1. Armaka M, Papanikolaou E, Sivropoulou A.et al.Antiviral properties of isoborneol, a potent inhibitor of herpes simplex virus type 1.Antiviral Res. 1999 Sep;43(2):79-92. 2. Bl?Ske V U , Hertel H , Forschler B T . Repellent Effects of Isoborneol on Subterranean Termites (Isoptera: Rhinotermitidae) in Soils of Different Composition[J]. Journal of Economic Entomology(4):4.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Tobacco Monomer Library Miao medicine Compound Library Anti-Viral Compound Library Selected Plant-Sourced Compound Library Anti-infective Natural Product Library RO5 Drug-like Natural Product Library Anti-Infection Compound Library Chinese Pharmacopoeia Natural Product Library Anti-virus Traditional Chinese Medicine Monomer Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Isoborneol 124-76-5 Microbiology/Virology HSV antiviral inhibit SH-SY5Y Herpes simplex virus DL-Isoborneol Inhibitor antioxidant neuroprotective nervous (±)-Isoborneol ROS plants inhibitor

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