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Isoniazid

Catalog No. T0972 CAS 54-85-3

Synonyms: INH, Isonicotinic acid hydrazide, Isonicotinic hydrazide

Isoniazid (Isonicotinic hydrazide) is an antibacterial agent used primarily as a tuberculostatic.

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Isoniazid, CAS 54-85-3

Pack Size	Availability	Price/USD
50 mg	In stock	$ 36.00
100 mg	In stock	$ 50.00
200 mg	In stock	$ 60.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 99.21%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Isoniazid (Isonicotinic hydrazide) is an antibacterial agent used primarily as a tuberculostatic.
In vitro	Isoniazid is a prodrug that requires activation by the mycobacterial catalase-peroxidase enzyme (KatG) to an active form that then exerts a lethal effect on an intracellular target or targets. [1] Isoniazid upregulates the expression of an operon containing five FAS II components, including kasA and acpM. Isoniazid results in the accumulation of ACP-bound lipid precursors to mycolic acids that are 26 carbons long and fully saturated. [2] Isoniazid enters the mycobacterial cell by passive diffusion. Isoniazid itself is not toxic to the bacterial cell, but acts as a prodrug and is activated by the mycobacterial enzyme KatG, a multifunctional catalase-peroxidase that has other activities, including peroxynitritase and NADH oxidase. Isoniazid inhibits cell wall lipid synthesis, coupled with the findings that inhibitory INH adducts of NAD+/NADP+ are formed from the isonicotinoyl radical, leading the field away from this area. [3] Isoniazid induces a concentration-dependent (0-40 mM) cytotoxic effect in day-1 treated HepG2 cells and not significantly affected by decreases in intracellular GSH concentrations. [4]
In vivo	Isoniazid increases CYP2E1 protein, and the 6-hydroxychlorzoxazone formation rate is increased by 2.7 and 2.2-fold in liver and kidney, respectively. Isoniazid decreases liver and kidney 20-HETE content to 34% and 15.6% of control, respectively, without significantly altering tissue 19-HETE concentration. [5]

Synonyms	INH, Isonicotinic acid hydrazide, Isonicotinic hydrazide
Molecular Weight	137.14
Formula	C6H7N3O
CAS No.	54-85-3

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 26 mg/mL (189.6 mM)

H2O: 25 mg/mL (182.3 mM)

Ethanol: 26 mg/mL (189.6 mM)

References and Literature

1. Mdluli K, et al. Science, 1998, 280(5369), 1607-1610. 2. Slayden RA, et al. Mol Microbiol, 2000, 38(3), 514-525. 3. Timmins GS, et al. Mol Microbiol, 2006, 62(5), 1220-1227. 4. Nicod L, et al. Hum Exp Toxicol, 1997, 16(1), 28-34. 5. Poloyac SM, et al. Drug Metab Dispos, 2004, 32(7), 727-733.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library FDA-Approved Drug Library Bioactive Compounds Library Max Approved Drug Library Anti-Cancer Metabolism Compound Library Toxic Compound Library Target-Focused Phenotypic Screening Library Covalent Inhibitor Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Isoniazid 54-85-3 Autophagy Metabolism Microbiology/Virology oxidation-reduction Antibacterial Dehydrogenase Mitophagy CAT inhibit mycobacteria INH Bacterial Mitochondrial Autophagy KatG Inhibitor Isonicotinic acid hydrazide Isonicotinic hydrazide tuberculostatic inhibitor

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