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JTE-013

Catalog No. T15629 CAS 383150-41-2

JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 nM, respectively).

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JTE-013, CAS 383150-41-2

Pack Size	Availability	Price/USD
5 mg	In stock	$ 70.00
10 mg	In stock	$ 101.00
25 mg	In stock	$ 224.00
50 mg	In stock	$ 336.00
1 mL * 10 mM (in DMSO)	In stock	$ 79.00

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Purity: 98.87%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 nM, respectively).
Targets&IC50	S1P2 (rat):22 nM, S1P2 (human):17 nM
In vitro	JTE-013 is a S1P2 antagonist. JTE-013 (50-200 μM;?1-3 days) decreased cell viability.?JTE-013 shows 4.2% inhibition of S1P3 and does not antagonize S1P1 at concentrations up to 10 μM.?JTE-013 (10-1000 nM;?30 mins) reverses S1P-induced Akt inhibition and inhibits S1P-induced ERK activation.
In vivo	JTE-013 (gavage;?30 mg/kg daily for 14 consecutive days) decreases tumor size and tumor weight.?the modification of JTE-013 to produce the AB1 compound improved potency, intravenous pharmacokinetics, cellular activity, and antitumor activity in NB and may have enhanced clinical and experimental applicability.

Molecular Weight	408.29
Formula	C17H19Cl2N7O
CAS No.	383150-41-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (244.92 mM), Sonication is recommended.

References and Literature

1. Li MH, et al. Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma. J Pharmacol Exp Ther. 2015 Sep;354(3):261-8.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library GPCR Compound Library Bioactive Compounds Library Max Covalent Inhibitor Library Apoptosis Compound Library NO PAINS Compound Library Bioactive Compound Library Anti-Cancer Compound Library ReFRAME Related Library

Related Products

Related compounds with same targets

MPI-0479605 ZZW-115 hydrochloride SB 202190 PTC-028 trans-Chalcone Umbelliferone W-7 hydrochloride SC-43

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

JTE-013 383150-41-2 Apoptosis GPCR/G Protein S1P Receptor LPL Receptor Inhibitor Lysophospholipid Receptor JTE013 inhibit JTE 013 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.