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KX1-004

Catalog No. T1812Cas No. 518058-84-9
Alias KX1004, KX1 004

KX1-004, a potential protective drug for NIHL, is an effective small molecule inhibitor of Src-PTK.

KX1-004

KX1-004

Purity: 99.42%
Catalog No. T1812Alias KX1004, KX1 004Cas No. 518058-84-9
KX1-004, a potential protective drug for NIHL, is an effective small molecule inhibitor of Src-PTK.
Pack SizePriceAvailabilityQuantity
1 mg$38In Stock
2 mg$54In Stock
5 mg$89In Stock
10 mg$163In Stock
25 mg$297In Stock
50 mg$490In Stock
100 mg$690In Stock
500 mg$1,450In Stock
1 mL x 10 mM (in DMSO)$98In Stock
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Purity:99.42%
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Product Introduction

Bioactivity
Description
KX1-004, a potential protective drug for NIHL, is an effective small molecule inhibitor of Src-PTK.
Targets&IC50
Src PTK:40 μM
Kinase Assay
The Lck HTRF kinase assay involves ATP-dependent phosphorylation of a biotinylated substrate peptide of gastrin in the presence or absence of inhibitor compound. The final concentration of gastrin is 1.2 μM. The final concentration of ATP is 0.5 μM (Km app =0.6±0.1 μM), and the final concentration of Lck (a GST-kinase domain fusion (AA 225?509)) is 250 pM. Buffer conditions are as follows: 50 mM HEPES pH=7.5, 50 mM NaCl, 20 mM MgCl2, 5 mM MnCl2, 2 mM DTT, 0.05% BSA. The assay is quenched and stopped with 160 μL of detection reagent. Detection reagents are as follows: Buffer made of 50 mM Tris, pH=7.5, 100 mM NaCl, 3 mM EDTA, 0.05% BSA, 0.1% Tween20. Prior to reading, Streptavidin allophycocyanin (SA-APC) is added at a final concentration in the assay of 0.0004 mg/mL, along with europilated anti-phosphotyrosine Ab (Eu-anti-PY) at a final conc of 0.025 nM. The assay plate is read in a Discovery fluorescence plate reader with excitation at 320 nm and emission at 615 and 655 nm[1].
AliasKX1004, KX1 004
Chemical Properties
Molecular Weight284.29
FormulaC16H13FN2O2
Cas No.518058-84-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 60 mg/mL (211.05 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.5175 mL17.5877 mL35.1753 mL175.8767 mL
5 mM0.7035 mL3.5175 mL7.0351 mL35.1753 mL
10 mM0.3518 mL1.7588 mL3.5175 mL17.5877 mL
20 mM0.1759 mL0.8794 mL1.7588 mL8.7938 mL
50 mM0.0704 mL0.3518 mL0.7035 mL3.5175 mL
100 mM0.0352 mL0.1759 mL0.3518 mL1.7588 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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