Powder: -20°C for 3 years | In solvent: -80°C for 1 year
L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM)
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 31.00 | |
2 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 228.00 | |
50 mg | In stock | $ 397.00 | |
100 mg | In stock | $ 589.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 79.00 |
Description | L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM) |
Targets&IC50 | NK1:2.3 nM |
In vitro | L-732,138 against three human melanoma cell lines (COLO 858, MEL HO, COLO 679).?L-732,138 elicits cell growth inhibition in a concentration dependent manner in the melanoma cells studied.?Moreover, L-732,138 blocks SP mitogen stimulation.?The specific antitumor action of L-732,138 occurred through the NK-1 receptor and melanoma cell death was by apoptosis[1]. |
In vivo | L-732138?Abolished the vagally-induced plasma leakage in tracheobronchial tissues, and dose-dependently inhibited the LPS enhanced vagally-induced plasma exudation in traceobronchial tissues[2]. |
Cell Research | Cell Line:COLO 858, MEL HO and COLO 679 cells. Concentration:0 μM, 20 μM, 40 μM, 60 μM, 80 μM, 100 μM. Incubation Time:First doubling time[1]. |
Animal Research | Animal Model:Male Dunkin-Hartley guinea-pigs (350-500 g) injected with lipopolysaccharide (LPS)[3].Dosage:10-4 mol/kg ,10-3 mol/kg and 10-2 mol/kg. Administration:Intravenous injection; for 15 minutes[2] |
Molecular Weight | 472.38 |
Formula | C22H18F6N2O3 |
CAS No. | 148451-96-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.72 mg/mL (10 mM)
You can also refer to dose conversion for different animals. More
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L-732138 148451-96-1 GPCR/G Protein Neuroscience Neurokinin receptor cytotoxicity vagally-induced NK receptor Neurokinin Receptor Inhibitor ntravenously lipopolysaccharide plasma Tachykinin receptor stimulation L 732138 mitogen peralgesia inhibit Antitumorhy L732138 apoptotic inhibitor