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L-732138

L-732138
L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM)
Catalog No. T8235Cas No. 148451-96-1
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Purity:99.77%
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L-732138

Catalog No. T8235Cas No. 148451-96-1
L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM)
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$43In Stock
10 mg$73In Stock
25 mg$137In Stock
50 mg$238In Stock
100 mg$353In Stock
200 mg$493In Stock
1 mL x 10 mM (in DMSO)$47In Stock
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Product Introduction

Bioactivity
Description
L-732138 is a potent and competitive antagonist of neurokinin-1 (NK-1) receptor(IC50 : 2.3 nM)
Targets&IC50
NK1:2.3 nM
In vitro
L-732,138 against three human melanoma cell lines (COLO 858, MEL HO, COLO 679).?L-732,138 elicits cell growth inhibition in a concentration dependent manner in the melanoma cells studied.?Moreover, L-732,138 blocks SP mitogen stimulation.?The specific antitumor action of L-732,138 occurred through the NK-1 receptor and melanoma cell death was by apoptosis[1].
In vivo
L-732138?Abolished the vagally-induced plasma leakage in tracheobronchial tissues, and dose-dependently inhibited the LPS enhanced vagally-induced plasma exudation in traceobronchial tissues[2].
Cell Research
Cell Line:COLO 858, MEL HO and COLO 679 cells. Concentration:0 μM, 20 μM, 40 μM, 60 μM, 80 μM, 100 μM. Incubation Time:First doubling time[1].
Animal Research
Animal Model:Male Dunkin-Hartley guinea-pigs (350-500 g) injected with lipopolysaccharide (LPS)[3].Dosage:10-4 mol/kg ,10-3 mol/kg and 10-2 mol/kg. Administration:Intravenous injection; for 15 minutes[2]
Chemical Properties
Molecular Weight472.38
FormulaC22H18F6N2O3
Cas No.148451-96-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 4.72 mg/mL (10 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1169 mL10.5847 mL21.1694 mL105.8470 mL
5 mM0.4234 mL2.1169 mL4.2339 mL21.1694 mL
10 mM0.2117 mL1.0585 mL2.1169 mL10.5847 mL

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