Shopping Cart

Remove All

Your shopping cart is currently empty

Laropiprant

Select Batch

Resource Download

COA HPLC

Laropiprant

Catalog No. T15712Cas No. 571170-77-9

Laropiprant (MK-0524) is a potent and selective antagonist of prostaglandin D2 (PGD2) receptor (DP) such as and DP/DP1 receptor(Ki = 0.57 nM) and TP Receptor(Ki = 2.95 nM).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$54	In Stock
2 mg	$78	In Stock
5 mg	$132	In Stock
10 mg	$192	In Stock
25 mg	$385	In Stock
50 mg	$592	In Stock
100 mg	$845	In Stock
500 mg	$1,690	In Stock
1 mL x 10 mM (in DMSO)	$145	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "Laropiprant"

Product Introduction

Bioactivity

Description	Laropiprant (MK-0524) is a potent and selective antagonist of prostaglandin D2 (PGD2) receptor (DP) such as and DP/DP1 receptor(Ki = 0.57 nM) and TP Receptor(Ki = 2.95 nM).
In vitro	Laropiprant blocks DP receptor-dependent enhance in VASP phosphorylation, as well as inhibition of P-selectin expression, GPIIb/IIIa activation, and in vitro thrombus formation. Laropiprant antagonizes the increased platelet aggregation by TP and EP3 receptor activation. Laropiprant (1 μM) induces a significant inhibition of the aggregation but still counteracts the pronounced inhibition caused by PGD2 (30 nM) and BW245c (3 nM). Laropiprant (10 μM) and niacin inhibit in vitro thrombus formation[2].
Alias	MK-0524

Chemical Properties

Molecular Weight	435.9
Formula	C21H19ClFNO4S
Cas No.	571170-77-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (229.41 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2941 mL	11.4705 mL	22.9410 mL	114.7052 mL
5 mM	0.4588 mL	2.2941 mL	4.5882 mL	22.9410 mL
10 mM	0.2294 mL	1.1471 mL	2.2941 mL	11.4705 mL
20 mM	0.1147 mL	0.5735 mL	1.1471 mL	5.7353 mL
50 mM	0.0459 mL	0.2294 mL	0.4588 mL	2.2941 mL
100 mM	0.0229 mL	0.1147 mL	0.2294 mL	1.1471 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc