glucuronide

6-Chloro-3-indolyl-β-D-Glucuronide (cyclohexylammonium salt) is a chromogenic substrate for β-glucuronidase. 6-Chloro-3-indolyl-β-D-Glucuronide (cyclohexylammonium salt) can be used in the histochemical analysis of β-glucuronidase activity.

Oroxylin A 7-O-β-d-glucuronide was a new alkaloid which found in the bulbs of Lycoris radiata.

Genistein 7-O-glucuronide is a natural product for research related to life sciences. The catalog number is TN4125 and the CAS number is 38482-81-4.

Propofol β-D-glucuronide is a metabolite of propofol sulfate , a short-acting anesthetic agent. [1] [2] The metabolite is generated through the glucuronidation of propofol by uridine diphosphate glucuronosyltransferases. Propofol metabolism appears to occur more rapidly in women than men. [1]

Cholesterol glucuronide is an endogenous metabolite of lipid generated by UDP glucuonyltransferase in the liver.

Silodosin glucuronide is an active metabolite of the α1A-adrenergic receptor antagonist silodosin . It is formed from silodosin by the UDP-glucuronosyltransferase (UGT) isoform UGT2B7. Silodosin glucuronide is toxic to rats with an LD50 value of 0.347 mg/kg.

(R,S)-Carvedilol glucuronide is a racemic mixture of the carvedilol metabolites (R)-carvedilol glucuronide and (S)-carvedilol glucuronide. (R)-Carvedilol glucuronide is formed via glucuronidation of (R)-carvedilol by the UDP-glucuronosyltransferase (UGT) isoforms UGT1A1 and UGT2B4. (S)-Carvedilol glucuronide is formed via glucuronidation of (S)-carvedilol by UGT2B4 and UGT2B7.

Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene.

(-)-Sitagliptin carbamoyl glucuronide is a minor phase II metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor (-)-sitagliptin . (-)-Sitagliptin carbamoyl glucuronide is formed by N-carbamoyl glucuronidation and has been found in rat and dog plasma following administration of (-)-sitagliptin.

MAC glucuronide linker-1 is a nonclaevable ADC linker for antibody-drug-conjugations (ADCs).

Isoscutellarein 8-O-β-D-glucuronide, a flavonoid antioxidant, can be isolated from the seeds of Theobroma grandiflorum [1] [2].

Febuxostat acyl glucuronide is a metabolite of the xanthine oxidoreductase inhibitor febuxostat . Febuxostat acyl glucuronide is formed via glucuronidation of febuxostat by uridine diphosphate-glucuronosyltransferases (UGTs).

Luteolin 7,3'-di-O-glucuronide is a natural product for research related to life sciences. The catalog number is TN4464 and the CAS number is 53965-08-5.

Acetaminophen glucuronide is an inactive metabolite of the analgesic and antipyretic agent acetaminophen . It is formed via glucuronidation of acetaminophen by the UDP-glucuronosyltransferase (UGT) isoforms UGT1A6, UGT1A9, UGT1A1, and UGT2B15.

Resveratrol-4'-O-D-Glucuronide has anti-fat accumulation properties, is metabolized by resveratrol, and can be used in metabolism-related studies.

Tricin 7-O-glucuronide is a flavonoid from Alfalfa (Medicago sativa L.).

β-D-glucuronide-pNP-carbonate is an ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs).

Ethylmalonic acid is potentially toxic, non-carcinogenic, and has been associated with anorexia nervosa and methoxy decarboxylase deficiency.

Axillarin 4'-glucuronide is a useful organic compound for research related to life sciences. The catalog number is T124474 and the CAS number is 65039-74-9.

Raloxifene 6,4'-Bis-β-D-glucuronide is a Raloxifene metabolite. Raloxifene is a selective antagonist of estrogen receptor for the prevention of osteoporosis.

Daidzein 7-O-glucuronide is a natural product for research related to life sciences. The catalog number is TN3752 and the CAS number is 38482-80-3.

Menthol glucuronide is a metabolite of L-(-)-Menthol, the natural form of Methanol.

Compound 5, DDC 3′-O-β-D-glucuronide, is a drug metabolite with properties that inhibit the fibrillization and oligomerization of Aβ42, suggesting its potential utility in Alzheimer's disease research [1].

Levothyroxine acyl glucuronide (Thyroxine Acyl-β-D-glucuronide), the acyl glucuronide formation of thyroxine (T4), an endogenous metabolite.

Hispidulin 7-glucuronide is a flavonoid that can be extracted from the leaves of mistletoe and has potential anti-inflammatory activity, inhibiting the release of IL-6.

Telmisartan acyl-β-D-glucuronide is a major metabolite of the angiotensin II receptor antagonist telmisartan . It does not bind human serum albumin and is cleared from rat plasma with a clearance rate of 180 ml/min/kg following intravenous administration.

Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran . The prodrug of dabigatran, dabigatran etexilate , is hydrolyzed by plasma esterases to form dabigatran, which is metabolized primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT2B15 to form dabigatran acyl-β-D-glucuronide. Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma equipotently to dabigatran.

Fulvestrant 3-β-D-Glucuronide, a glucuronide and sulfate conjugate metabolite of the pure anti-estrogenic steroid Fulvestrant, is utilized in breast cancer research [1].

β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE (compound 20), an auristatins-glucuronide conjugate, exhibits in vitro antiproliferative effects on cancer cells, both β-glucuronidase pretreated and untreated, with an IC50 range of 5.7 nM to 9.7 nM. Demonstrating powerful antitumor efficacy in an HCT-116 xenograft mouse model, this compound does not induce side effects [1].

all-trans Retinoyl β-D-glucuronide is a metabolite of all-trans retinoic acid formed by the UDP-glucuronosyltransferase (UGT) system. It is rapidly converted to all-trans retinoic acid following in vitro or in vivo administration.

Estriol-3-glucuronide, a natural compound found in urine, is also present in amniotic fluid during normal pregnancy [1][2].

Oroxylin A 7-O-β-D-glucuronide methyl ester, a natural product, can be isolated from the roots of Scutellaria baicalensis Georgi [1].

Etodolac acyl glucuronide is a phase II metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor etodolac .1It is formedviaglucuronidation of etodolac by the UDP-glucuronosyltransferase (UGT) isoforms UGT1A9, UGT1A10, and UGT2B7. 1.Kutsuno, Y., Itoh, T., Tukey, R.H., et al.Glucuronidation of drugs and drug-induced toxicity in humanized UDP-glucuronosyltransferase 1 miceDrug Metab. Dispos.42(7)1146-1152(2014)

7-hydroxy Coumarin glucuronide is a 7-hydroxy coumarin phase II metabolite that can be used as a standard for the analysis of 7-hydroxy coumarin metabolism.

SN-38 glucuronide, an inactive metabolite of Irinotecan, serves as a derivative of this cancer-fighting agent. Irinotecan, known for inhibiting topoisomerase I, is utilized in the research of colon and rectal cancer [1].

Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil , is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM.

Estrone 3-glucuronide, a deuterium-labeled version, is recognized as the primary metabolite of estradiol and serves as a urinary marker for predicting the fertile window [1].

Quercetin 7-glucuronide (Quercetin 7-O-β-glucuronide), a Quercetin metabolite found in Madagascarian Uncarina species, has the capability to inhibit LDL oxidation [1].

T3 Acyl glucuronide is the acyl glucuronide formation of triiodothyronine (T3). T3 Acyl glucuronide is an endogenous metabolite

Formoterol O-β-D-glucuronide is a metabolite of formoterol .

Naringenin-7-O-β-D-glucuronide, a metabolite of the flavonoid naringenin, is predominantly synthesized through the action of UDP-glucuronosyltransferase (UGT) isoforms UGT1A1, UGT1A3, UGT1A6, and UGT1A9.

Chlorzoxazone N-glucuronide is a phase II metabolite of the skeletal muscle relaxant chlorzoxazone . Chlorzoxazone N-glucuronide is formed via glucuronidation of chlorzoxazone by the UDP-glucuronosyltransferase (UGT) isoform UGT1A9.

Ethyl glucuronide is an endogenous metabolite.

β-Glucuronide-dPBD-PEG5-NH2 TFA is a β-glucuronide-linked pyrrolobenzodiazepine dimer employed in the synthesis of the antibody-drug conjugate (ADC) cIRCR201-dPBD, utilizing a cleavable β-glucuronide linkage. Serving as a proagent, it aims to mitigate side effects, inducing apoptosis and arresting the cell cycle, thereby exhibiting antitumor activity [1].

Tolmetin β-D-Glucuronide has reactive properties with human serum albumin, allowing identification of the binding site and reaction mechanism by tandem mass spectrometry.

Eriodictyol 7-O-glucuronide is a natural product for research related to life sciences. The catalog number is TN5522 and the CAS number is 125535-06-0.

(±)-4-hydroxy Propranolol β-D-glucuronide is a metabolite of (±)-4-hydroxy propranolol , which is a metabolite of propranolol. The apparent half-life of (±)-4-hydroxy propranolol β-D-glucuronide is similar to propranolol and 4-hydroxy propranolol. Propranolol is a β-adrenergic antagonist, and the active enantiomer, (S)-(-)-propranolol , has log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively.

1-Salicylate glucuronide is a metabolite of salicylic acid and aspirin .1It is formed from salicylic acid primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A9 but also by a variety of other UGT isoforms and from aspirinviasalicylic acid as an intermediate. 1.Kuehl, G.E., Bigler, J., Potter, J.D., et al.Glucuronidation of the aspirin metabolite salicylic acid by expressed UDP-glucuronosyltransferases and human liver microsomesDrug Metab. Dispos.34(2)199-202(2006)

Mycophenolic Acid-d3 Phenyl Glucuronide is a deuterated compound of Mycophenolic Acid Phenyl Glucuronide. Mycophenolic Acid Phenyl Glucuronide has a CAS number of 31528-44-6. Mycophenolic acid glucuronide is the glucuronide metabolite of mycophenolic acid in human plasma.

Acacetin-7-glucuronide is a useful organic compound for research related to life sciences. The catalog number is T124926 and the CAS number is 38226-83-4.