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ML-099

Catalog No. T22991 CAS 496775-95-2

ML-099 is a pan Ras-related GTPases activator that activates Rac1, Ras, GTP-binding protein (Rab7), Rab2A and cell division cycle 42.

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ML-099, CAS 496775-95-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 41.00
2 mg	In stock	$ 58.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 155.00
25 mg	In stock	$ 322.00
50 mg	In stock	$ 513.00
100 mg	In stock	$ 747.00
1 mL * 10 mM (in DMSO)	In stock	$ 95.00

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Purity: 99.48%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ML-099 is a pan Ras-related GTPases activator that activates Rac1, Ras, GTP-binding protein (Rab7), Rab2A and cell division cycle 42.
Targets&IC50	Rac1:20.17 nM(wild type,EC50), Rac1:25.42 nM(activated mutant,EC50), Cell division cycle 42:100 nM(wild type,EC50), Cell division cycle 42:58.88 nM(activated mutant,EC50), Ras:95.5 nM(activated mutant,EC50)
In vitro	ML-099 activates Ras protein wild type(EC50 = 141.25 nM), Rab7(EC50 = 181.97 nM), Rab-2A(EC50 = 354.81 nM), Rac1 protein activated mutant(EC50 = 25.42 nM), Rac1 protein wild type(EC50 = 20.17 nM), Ras protein activated mutant(EC50 = 95.5 nM), cell division cycle 42 activated mutant(EC50 = 58.88 nM) and cell division cycle 42 wild type(EC50 = 100 nM)[1].

Molecular Weight	259.32
Formula	C14H13NO2S
CAS No.	496775-95-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: ≤ 10 mg/mL

References and Literature

1. Surviladze, Z., et al. UNMCMD Probe Report: Three small molecule pan activator families of Ras-related GTPases. 1-42 (2010-2009 May 18).

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Kinase Inhibitor Library Membrane Protein-targeted Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Bioactive Compound Library Anti-Ovarian Cancer Compound Library Exosome Compound Library Anti-Liver Cancer Compound Library Anti-Prostate Cancer Compound Library

Related Products

Related compounds with same targets

Digeranyl bisphosphonate YH-306 SAR407899 ITX3 EHop-016 GGTI 2147 Zoledronic Acid CCG-100602

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ML-099 496775-95-2 Cell Cycle/Checkpoint GPCR/G Protein MAPK Ras Rho inhibit Inhibitor CID 888706 Rab7 Rac1 ab-2A ML 099 CID888706 ML099 CID-888706 inhibitor

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