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Magnolol

Catalog No. T3000   CAS 528-43-8
Synonyms: NSC 293099, 5,5'-Diallyl-2,2'-biphenyldiol

Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.

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Magnolol Chemical Structure
Magnolol, CAS 528-43-8
Pack Size Availability Price/USD Quantity
10 mg In stock $ 39.00
25 mg In stock $ 66.00
50 mg In stock $ 97.00
100 mg In stock $ 155.00
500 mg In stock $ 389.00
1 mL * 10 mM (in DMSO) In stock $ 43.00
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Purity: 100%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
Targets&IC50 PPARγ:17.7 μM (EC50), RXRα:10.4 μM (EC50)
In vitro Magnolol shows significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 μg/ml.
Source
Synonyms NSC 293099, 5,5'-Diallyl-2,2'-biphenyldiol
Molecular Weight 266.33
Formula C18H18O2
CAS No. 528-43-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 49 mg/mL (184 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 49 mg/mL (184 mM)

TargetMolReferences and Literature

1. Ai J, et al. Pharmacology, 2001, 63(1), 34-41. 2. Bang KH, et al. Arch Pharm Res, 2000, 23(1), 46-49. 3. Kuang Y, Chai Y, Xu L, et al. Glabrone as a specific UGT1A9 probe substrate and its application in discovering the inhibitor glycycoumarin[J]. European Journal of Pharmaceutical Sciences. 2021: 105786.

TargetMolCitations

1. Kuang Y, Chai Y, Xu L, et al. Glabrone as a specific UGT1A9 probe substrate and its application in discovering the inhibitor glycycoumarin. European Journal of Pharmaceutical Sciences. 2021: 105786.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Neurodegenerative Disease Compound Library Food as Medicine Compound Library NF-κB Signaling Compound Library Glycometabolism Compound Library Anti-Cancer Metabolism Compound Library Transcription Factor-Targeted Compound Library Anti-Breast Cancer Compound Library Selected Plant-Sourced Compound Library

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Keywords

Magnolol 528-43-8 Apoptosis Autophagy DNA Damage/DNA Repair Metabolism Microbiology/Virology NF-Κb Antibacterial PPAR Retinoid Receptor NF-κB p53 inhibit RAR/RXR Retinoic acid receptors NSC 293099 NSC-293099 Retinoid X receptors 5,5'-Diallyl-2,2'-biphenyldiol NSC293099 Inhibitor Peroxisome proliferator-activated receptors Bacterial inhibitor

 

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