Shopping Cart
- Remove All
Your shopping cart is currently empty
Milademetan
Milademetan (DS-3032) is an orally active and potent MDM2 inhibitor with antitumor activity that induces G1 cell cycle arrest, senescence, and apoptosis.Milademetan is used in the study of acute myeloid leukemia and solid tumors.
Catalog No. T12040Cas No. 1398568-47-2
Select Batch
Purity:100%
Contact us for more batch information
Milademetan
Catalog No. T12040Alias RAIN-32, DS3032b, DS-3032Cas No. 1398568-47-2
Milademetan (DS-3032) is an orally active and potent MDM2 inhibitor with antitumor activity that induces G1 cell cycle arrest, senescence, and apoptosis.Milademetan is used in the study of acute myeloid leukemia and solid tumors.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $178 | In Stock | |
| 5 mg | $546 | In Stock | |
| 10 mg | $793 | In Stock | |
| 25 mg | $1,090 | In Stock | |
| 50 mg | $1,530 | In Stock | |
| 100 mg | $1,980 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $30 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Milademetan"
XI-006
NSC 207895
T661058131-57-0
XI-006 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
- $51
Size
QTY
RITA
Cited
RITA (NSC 652287), NSC 652287
T1798213261-59-7
RITA (NSC-652287)(NSC-652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 interaction.
- $30
Size
QTY
CitedIdasanutlin Cited
Ro 5503781, RG7388
T62541229705-06-9
Idasanutlin (Ro 5503781) (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).
- $34
Size
QTY
CitedAlrizomadlin
APG-115, AA-115
T143031818393-16-6
Alrizomadlin is an orally active MDM2 inhibitor. APG-115 shows significant dose-dependent inhibitory effects on TP53wt AML cell lines. The IC50 values are 26.8 nM for MOLM-13 cells and 165.9 nM for MV-4-11 cells. , OCI-AML-3 cells 315.6 nM. Alrizomadlin blocks the interaction of MDM2 and p53 and induces cell cycle arrest and apoptosis in a p53-dependent manner.
- $263
Size
QTY
RG7112
RO5045337, RG-7112, RG 7112
T6965939981-39-2
RG7112 (RO5045337) (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor.
- $41
Size
QTY
Navtemadlin
CS-1300, AMG232
TQ01271352066-68-2
Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.
- $67
Size
QTY
RDR03871
ZINC20458540, RDR-03871, RDR 03871
T28509286008-51-3In house
RDR03871 is an MDM2 inhibitor.
- $117
Size
QTY
MMRi64
T28078430458-66-5
MMRi64 is a specific inhibitor of Mdm2-MdmX E3 ligase activity.MMRi64 potently induces p53 accumulation and apoptosis in the p53 pathway in leukemia/lymphoma cells, disrupts Mdm2-MdmX interactions, and downregulates Mdm2 and MdmX in leukemia cells.MMRi64 MMRi64 can be used in cancer research.
- $51
Size
QTY
RO-5963
T167711416663-77-8In house
RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, respectively).
- $106
Size
QTY
Serdemetan Cited
JNJ-26854165
T2243881202-45-5
Serdemetan (JNJ-26854165) is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.
- $39
Size
QTY
CitedSAR405838
MI-77301, MI-773, MI773, MI 773
T65851303607-60-4In house
MI-773 (SAR405838 (MI 773)) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.
- $45
Size
QTY
p53-MDM2-IN-1
T72026381717-91-5
p53-MDM2-IN-1 (Example 30), an inhibitor of the p53-MDM2/X protein interaction, exhibits a K i value of 23.35 µM and holds potential for applications in anti-tumor research.
- $195
Size
QTY
Product Introduction
Bioactivity
Chemical Properties
| Description | Milademetan (DS-3032) is an orally active and potent MDM2 inhibitor with antitumor activity that induces G1 cell cycle arrest, senescence, and apoptosis.Milademetan is used in the study of acute myeloid leukemia and solid tumors. |
| In vitro | Milademetan (DS-3032) selectively induces CDKNA1, BAX, and MDM2 expression and stabilizes TP53 in neuroblastoma cells with wild-type TP53[3]. Treatment with Milademetan (DS-3032) enhances TP53 target gene expression, leading to G1 cell cycle arrest, senescence, and apoptosis[3]. In neuroblastoma cells with wild-type TP53, independent of MYCN status, Milademetan (DS-3032, 0-2000 nM) treatment selectively inhibits viability, proliferation, and migration[2]. |
| In vivo | In mice xenografted with neuroblastoma cells possessing functional TP53, oral gavage administration of Milademetan (DS-3032) at a dose of 50 mg/kg delays tumor growth and improves overall survival[2]. |
| Alias | RAIN-32, DS3032b, DS-3032 |
| Molecular Weight | 618.53 |
| Formula | C30H34Cl2FN5O4 |
| Cas No. | 1398568-47-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (88.92 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Milademetan | purchase Milademetan | Milademetan cost | order Milademetan | Milademetan chemical structure | Milademetan in vivo | Milademetan in vitro | Milademetan formula | Milademetan molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.