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Milademetan

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Purity:100%

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COA FNMR HNMR LCMS

Milademetan

Catalog No. T12040Cas No. 1398568-47-2

Milademetan (DS-3032) is an orally active and potent MDM2 inhibitor with antitumor activity that induces G1 cell cycle arrest, senescence, and apoptosis.Milademetan is used in the study of acute myeloid leukemia and solid tumors.

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Pack Size	Price	Availability
1 mg	$178	In Stock
5 mg	$547	In Stock
10 mg	$913	In Stock
25 mg	$1,350	In Stock
50 mg	$1,820	In Stock
100 mg	$2,460	In Stock
500 mg	$4,930	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock

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Product Introduction

Bioactivity

Description	Milademetan (DS-3032) is an orally active and potent MDM2 inhibitor with antitumor activity that induces G1 cell cycle arrest, senescence, and apoptosis.Milademetan is used in the study of acute myeloid leukemia and solid tumors.
In vitro	Milademetan (DS-3032) selectively induces CDKNA1, BAX, and MDM2 expression and stabilizes TP53 in neuroblastoma cells with wild-type TP53[3]. Treatment with Milademetan (DS-3032) enhances TP53 target gene expression, leading to G1 cell cycle arrest, senescence, and apoptosis[3]. In neuroblastoma cells with wild-type TP53, independent of MYCN status, Milademetan (DS-3032, 0-2000 nM) treatment selectively inhibits viability, proliferation, and migration[2].
In vivo	In mice xenografted with neuroblastoma cells possessing functional TP53, oral gavage administration of Milademetan (DS-3032) at a dose of 50 mg/kg delays tumor growth and improves overall survival[2].
Alias	RAIN-32, DS-3032, DS3032b

Chemical Properties

Molecular Weight	618.53
Formula	C30H34Cl2FN5O4
Cas No.	1398568-47-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (88.92 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6167 mL	8.0837 mL	16.1674 mL	80.8368 mL
5 mM	0.3233 mL	1.6167 mL	3.2335 mL	16.1674 mL
10 mM	0.1617 mL	0.8084 mL	1.6167 mL	8.0837 mL
20 mM	0.0808 mL	0.4042 mL	0.8084 mL	4.0418 mL
50 mM	0.0323 mL	0.1617 mL	0.3233 mL	1.6167 mL

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