Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochloride can cause both an acute hepatitis-like syndrome occurring within 1 to 3 months of starting therapy or a more insidious chronic hepatitis with autoimmune features typically after long-term treatment.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 38.00 | |
50 mg | In stock | $ 50.00 | |
100 mg | In stock | $ 62.00 | |
200 mg | In stock | $ 92.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochloride can cause both an acute hepatitis-like syndrome occurring within 1 to 3 months of starting therapy or a more insidious chronic hepatitis with autoimmune features typically after long-term treatment. |
In vitro | Minocycline exhibits significant neuroprotective effects in models of cerebral ischemia, traumatic brain injury, Huntington's disease, and Parkinson's disease. Its neuroprotective properties may involve the inhibition of 5-lipoxygenase (an inflammatory enzyme associated with brain aging). Additionally, Minocycline's activity is linked to the inhibition of protein synthesis. |
In vivo | Minocycline inhibits the release of cytochrome c mediated by the permeability transition in mitochondria. This inhibition by minocycline on cytochrome c release has been demonstrated in vivo, in cells, and isolated mitochondria. Additionally, minocycline suppresses the activity of inducible caspase-1 and caspase-3, inducible nitric oxide synthase (iNOS), and p38 mitogen-activated protein kinase (MAPK). Following experimental focal ischemia, minocycline reduces the upregulation of caspase-1 and iNOS, thereby decreasing infarct size. |
Synonyms | Minocycline HCl |
Molecular Weight | 493.94 |
Formula | C23H28ClN3O7 |
CAS No. | 13614-98-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 12.4 mg/mL (25 mM)
DMSO: 49.4 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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Minocycline hydrochloride 13614-98-7 Chromatin/Epigenetic Metabolism Microbiology/Virology HIF/HIF Prolyl-Hydroxylase Antibiotic Antibacterial Calcium Channel Inhibitor HIF-PH Myocardial ischemia MDM-2/p53 PI3K/Akt Apoptosis Potassium Channel Minocycline HCl inhibit Ca2+ channels Hypoxia-inducible factors HIFs infection L-type Ca2+ channel stroke cerebral ischemia Ca channels acinetobacter neuroprotective Minocycline Minocycline Hydrochloride KcsA ovarian cancer Mitochondrial ATP-sensitive potassium Ventricular arrhythmia Bacterial inhibitor