Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 35.00 | |
5 mg | In stock | $ 57.00 | |
10 mg | In stock | $ 92.00 | |
25 mg | In stock | $ 197.00 | |
50 mg | In stock | $ 357.00 | |
100 mg | In stock | $ 587.00 | |
200 mg | In stock | $ 772.00 | |
500 mg | In stock | $ 1,190.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 63.00 |
Description | NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells. |
Targets&IC50 | PHGDH:2.5 μM |
In vitro | NCT-503 has reasonable aqueous solubility, and exhibits favorable absorption, distribution, metabolism and excretion (ADME) properties[1]. NCT-503 selectively blocks glucose-derived serine synthesis but at the same time triggers SHMT1-dependent one-carbon unit wasting to synthesize serine from glycine. This futile cycle depletes the cell of nucleotides and leads to cell cycle arrest |
In vivo | NCT-503 has good exposure (AUClast=14,700 hr*ng/mL), half-life (2.5 hr) and Cmax (~20 μM in plasma) following intraperitoneal administration with significant partitioning into the liver and brain. PHGDH inhibition by NCT-503 selectively increases necrosis in MDA-MB-468 xenografts, but not in MDA-MB-231 xenografts. It also reduces the growth and weight of PHGDH-dependent MDA-MB-468 xenografts but does not affect the growth or weight of PHGDH-independent MDA-MB-231 xenografts |
Animal Research | Animal Models: NOD.SCID mice bearing MDA-MB-231 and MDA-MB-468 orthotropic xenograftsFormulation: 5% ethanol, 35% PEG 300, and 60% of an aqueous 30% hydroxypropyl-β-cyclodextrin solutionDosages: 40 mg/kgAdministration: i.p.(Only for Reference) |
Synonyms | NCT 503 |
Molecular Weight | 408.48 |
Formula | C20H23F3N4S |
CAS No. | 1916571-90-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 75 mg/mL (183.6 mM)
DMSO: 75 mg/mL (183.6 mM)
You can also refer to dose conversion for different animals. More
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NCT-503 1916571-90-8 Angiogenesis Metabolism Tyrosine Kinase/Adaptors FLT Dehydrogenase TAM Receptor inhibit Inhibitor NCT503 NCT 503 inhibitor