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NVP-2

NVP-2
NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50: 0.514 nM). NVP-2 shows inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases (IC50: 0.584 μM, 0.706 μM, and 0.605 μM, respectively).
Catalog No. T16363Cas No. 1263373-43-8
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Purity:99.76%
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NVP-2

Purity: 99.76%
Catalog No. T16363Cas No. 1263373-43-8

NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50: 0.514 nM). NVP-2 shows inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases (IC50: 0.584 μM, 0.706 μM, and 0.605 μM, respectively).
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Pack SizePriceAvailabilityQuantity
1 mg$29In Stock
5 mg$73In Stock
10 mg$128In Stock
25 mg$278In Stock
50 mg$397In Stock
100 mg$583In Stock
200 mg$789In Stock
1 mL x 10 mM (in DMSO)$82In Stock
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Product Introduction

Bioactivity
Description
NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50: 0.514 nM). NVP-2 shows inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases (IC5
Targets&IC50
CDK9:0.5 nM (IC50)
In vitro
NVP-2 exhibits anti-proliferative activity against leukemia cells, specifically targeting KOPT-K1, Jurkat, P12-ICHIKAWA, DU.528, MOLT 16, HSB-2, PF-382, SKW-3, SUP-T11, DND-41, and HPB-ALL cells with IC50 values of 0.1688 μM, 0.1233 μM, 0.5736 μM, 0.1575 μM, 0.1620 μM, 0.1585 μM, 0.1808 μM, 0.2589 μM, 0.0918 μM, and 0.3023 μM, respectively. NVP-2 (0-10 nM; 72 hours) demonstrates CRBN-dependent anti-proliferative and pro-apoptotic effects in MOLT4 cells (IC50: 9 nM). At 250 nM for 24 hours, NVP-2 induces apoptosis in MOLT4 cells, increasing caspase-3 and γH2A.X expression, although this effect is significantly reduced upon compound washout. Additionally, NVP-2 (250 nM-1 μM; 6 hours) engages CDK9 in both wildtype and CRBN - / - MOLT4 cells without affecting CDK2 and CDK7.
Chemical Properties
Molecular Weight513.07
FormulaC27H37ClN6O2
Cas No.1263373-43-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (194.91 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9491 mL9.7453 mL19.4905 mL97.4526 mL
5 mM0.3898 mL1.9491 mL3.8981 mL19.4905 mL
10 mM0.1949 mL0.9745 mL1.9491 mL9.7453 mL
20 mM0.0975 mL0.4873 mL0.9745 mL4.8726 mL
50 mM0.0390 mL0.1949 mL0.3898 mL1.9491 mL
100 mM0.0195 mL0.0975 mL0.1949 mL0.9745 mL

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