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NVP-2

Catalog No. T16363 CAS 1263373-43-8

NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50: 0.514 nM). NVP-2 shows inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases (IC50: 0.584 μM, 0.706 μM, and 0.605 μM, respectively).

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NVP-2, CAS 1263373-43-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 50.00
2 mg	In stock	$ 72.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 213.00
25 mg	In stock	$ 463.00
50 mg	In stock	$ 683.00
100 mg	In stock	$ 973.00
1 mL * 10 mM (in DMSO)	In stock	$ 137.00

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Purity: 99.76%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50: 0.514 nM). NVP-2 shows inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases (IC50: 0.584 μM, 0.706 μM, and 0.605 μM, respectively).
Targets&IC50	CDK9:0.5 nM (IC50)
In vitro	NVP-2 has an anti-proliferation of leukemia cells, suppresses KOPT-K1, Jurkat, P12-ICHIKAWA, DU.528, MOLT 16, HSB-2, PF-382, SKW-3, SUP-T11, DND-41 and HPB-ALL cells with IC50 values of 0.1688 μM, 0.1233 μM,0.5736 μM,0.1575 μM, 0.1620 μM,0.1585 μM, 0.1808 μM, 0.2589 μM, 0.0918 μM and 0.3023 μM, respectively. NVP-2 (0-10 nM; 72 hours) shows CRBN-dependent anti-proliferative and pro-apoptotic effects in MOLT4 cells (IC50: 9 nM). NVP-2 (250 nM; 24 hours) causes cell apoptosis in MOLT4 cells, upregulates caspase-3 and γH2A.X expression. However, while the compound washout significantly reduces the degree of apoptosis induced by NVP-2. NVP-2 (250 nM-1 μM; 6 hours) engages CDK9 in wildtype and CRBN?/? MOLT4 cells at all concentrations, while CDK2 and CDK7 are unaffected.

Molecular Weight	513.07
Formula	C27H37ClN6O2
CAS No.	1263373-43-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (194.91 mM)

References and Literature

1. Winter GE, et al. BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment.Mol Cell. 2017 Jul 6;67(1):5-18.e19.

Citations

1. Shan X, Jiang R, Gou D, et al.Identification of a diketopiperazine‐based O‐GlcNAc transferase inhibitor sensitizing hepatocellular carcinoma to CDK9 inhibition.The FEBS Journal.2023 2. Wang J, Wen Y, Zhang Y, et al.An interpretable artificial intelligence framework for designing synthetic lethality-based anti-cancer combination therapies.Journal of Advanced Research.2023

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Cell Cycle Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Bioactive Compound Library Kinase Inhibitor Library Anti-Cancer Compound Library Anti-Pancreatic Cancer Compound Library Covalent Inhibitor Library Apoptosis Compound Library

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Keywords

NVP-2 1263373-43-8 Apoptosis Cell Cycle/Checkpoint CDK inhibit Cyclin dependent kinase NVP2 Inhibitor CRBN CDK9 Leukemia NVP 2 inhibitor

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