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Navarixin

Catalog No. T7130 CAS 473727-83-2

Synonyms: MK-7123, SCH 527123

Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking in animal models, characteristics that may be beneficial in the treatment of conditions with unbalanced pulmonary neutrophilia.

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Navarixin, CAS 473727-83-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 38.00
5 mg	In stock	$ 89.00
10 mg	In stock	$ 133.00
25 mg	In stock	$ 243.00
50 mg	In stock	$ 397.00
100 mg	In stock	$ 597.00
500 mg	In stock	$ 1,320.00
1 mL * 10 mM (in DMSO)	In stock	$ 97.00

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Purity: 98.63%

Purity: 98.23%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking in animal models, characteristics that may be beneficial in the treatment of conditions with unbalanced pulmonary neutrophilia.
Targets&IC50	CXCR2 (rat):0.2 nM (Kd), CXCR2 (mouse):0.2 nM (Kd), CXCR1 (cynomolgus):41 nM (Kd), [125I]-CXCL8-CXCR2:0.97 nM (IC50), CXCR2 (cynomolgus):0.08 nM (Kd), [125I]-CXCL8-CXCR1:43 nM (IC50)
In vitro	Navarixin is a potent, allosteric antagonist of both CXCR1 and CXCR2, with Kd values of 41 nM for cynomolgus CXCR1 and 0.20 nM, 0.20 nM, 0.08 nM for mouse, rat and cynomolgus monkey CXCR2, respectivelly[1].

Synonyms	MK-7123, SCH 527123
Molecular Weight	397.42
Formula	C21H23N3O5
CAS No.	473727-83-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (125.81 mM)

References and Literature

1. Gonsiorek W , Fan X , Hesk D , et al. Pharmacological Characterization of Sch527123, a Potent Allosteric CXCR1/CXCR2 Antagonist[J]. Journal of Pharmacology and Experimental Therapeutics, 2007, 322(2):477-485. 2. Holz O, Khalilieh S, Ludwig-Sengpiel A,et al.SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects[J].Eur Respir J. 2010 Mar;35(3):564-70.

Citations

1. Luo Q, Dong Z, Xie W, et al.Apatinib remodels the immunosuppressive tumor ecosystem of gastric cancer enhancing anti-PD-1 immunotherapy.Cell Reports.2023, 42(5).

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Inhibitor Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library GPCR Compound Library Target-Focused Phenotypic Screening Library Orally Active Compound Library Clinical Compound Library Autophagy Compound Library

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Keywords

Navarixin 473727-83-2 Autophagy GPCR/G Protein Immunology/Inflammation CXCR inhibit MK 7123 CXC chemokine receptors MK-7123 Inhibitor MK7123 SCH 527123 SCH527123 SCH-527123 inhibitor

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