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Nelociguat

Catalog No. T7201 CAS 625115-52-8

Synonyms: BAY60-4552

Nelociguat (BAY60-4552)(BAY60-4552) is a soluble guanylate cyclase stimulator (sGC stimulator). Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway.

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Nelociguat, CAS 625115-52-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 37.00
2 mg	In stock	$ 53.00
5 mg	In stock	$ 87.00
10 mg	In stock	$ 137.00
25 mg	In stock	$ 178.00
50 mg	In stock	$ 273.00
100 mg	In stock	$ 441.00
200 mg	In stock	$ 576.00
500 mg	In stock	$ 751.00
1 g	In stock	$ 945.00
1 mL * 10 mM (in DMSO)	In stock	$ 90.00

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Purity: 99.15%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Nelociguat (BAY60-4552)(BAY60-4552) is a soluble guanylate cyclase stimulator (sGC stimulator). Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway.
In vivo	Bilateral CN crush injury followed by a 3-wk recovery period decreased erectile responses to ES CN by about 50%. In CN-crushed rats, IV vardenafil 0.03 mg/kg and BAY 60-4552 (0.03 or 0.3 mg/kg) increased erectile responses to ES CN to the same extent: intracavernosal pressure/mean arterial pressure (ICP/MAP) at 10 Hz ES CN was 21±1% after vehicle, 25±3% (p<0.001) after vardenafil, and 26±5% and 27±5% after BAY 60-4552 0.03 mg/kg (p<0.01) and 0.3 mg/kg (p<0.001), respectively. The combination of vardenafil with BAY 60-4552 in CN-crushed rats totally restored erectile responses to ES CN equivalent to sham rats (ICP/MAP at 10 Hz ES CN: 34±4% after BAY 60-4552/vardenafil combination vs 39±4% in sham rats; not significant)[1].
Animal Research	The acute effects of intravenous (IV) injection of vehicle, vardenafil 0.03 mg/kg, BAY 60-4552 0.03 mg/kg or 0.3 mg/kg, or a BAY 60-4552 0.03 mg/kg plus vardenafil 0.03 mg/kg combination were evaluated in CN-crushed rats[1].

Synonyms	BAY60-4552
Molecular Weight	408.39
Formula	C19H17FN8O2
CAS No.	625115-52-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 105 mg/mL (257.11 mM)

References and Literature

1. Oudot A , Behr-Roussel D , Poirier S , et al. Combination of BAY 60-4552 and Vardenafil Exerts Proerectile Facilitator Effects in Rats With Cavernous Nerve Injury: A Proof of Concept Study for the Treatment of Phosphodiesterase Type 5 Inhibitor Failure[J]. European Urology, 2011, 60(5):1020-1026. 2. Costell M H , Nicolas A , Bernard R E , et al. Comparison of Soluble Guanylate Cyclase Stimulators and Activators in Models of Cardiovascular Disease Associated with Oxidative Stress[J]. Frontiers in Pharmacology, 2012, 3.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library GPCR Compound Library Drug Repurposing Compound Library Bioactive Compound Library Bioactive Compounds Library Max Clinical Compound Library NO PAINS Compound Library ReFRAME Related Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

Nelociguat 625115-52-8 GPCR/G Protein Guanylate cyclase inhibit Inhibitor Guanylate Cyclase BAY60-4552 inhibitor

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