Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Niaprazine is a histamine H1-receptor antagonist with marked sedative properties.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 40.00 | |
2 mg | In stock | $ 57.00 | |
5 mg | In stock | $ 89.00 | |
10 mg | In stock | $ 147.00 | |
25 mg | In stock | $ 248.00 | |
50 mg | In stock | $ 369.00 | |
100 mg | In stock | $ 543.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 97.00 |
Description | Niaprazine is a histamine H1-receptor antagonist with marked sedative properties. |
Targets&IC50 | 5-HT2:25 nM(Ki), α1-adrenoceptor:77 nM(Ki) |
In vitro | Niaprazine demonstrates a low affinity for the vesicular monoamine transporter as well as D2, α2, β, H1, and mAch receptors. Notably, the (+)stereoisomer of Niaprazine shows a significantly higher affinity for α1 (Ki = 77 nM) and 5-HT2 (Ki = 25 nM) binding sites, whereas it is poorly recognized by 5-HT1A and 5-HT1B binding sites[2]. |
In vivo | Niaprazine (60 mg/kg; i.p.; once) treatment increases rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 min after treatment, and reduced them at 3-8 hr after treatment. Niaprazine also produces a short-lasting depletion of rat brain noradrenaline (NA) and dopamine (DA)[3]. Animal Model: Male Sprague-Dawley rats (150-200 g)[3] |
Molecular Weight | 356.44 |
Formula | C20H25FN4O |
CAS No. | 27367-90-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (280.55 mM)
You can also refer to dose conversion for different animals. More
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Niaprazine 27367-90-4 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor 5-HT Receptor Adrenergic Receptor 5-HIAA disorders sleep autistic inhibit 5-HT2 sedative Inhibitor H1-receptor inhibitor