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Norethindrone

Catalog No. T1514 CAS 68-22-4

Synonyms: Norethisterone

Norethindrone (Norethisterone) is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.

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Norethindrone, CAS 68-22-4

Pack Size	Availability	Price/USD
50 mg	In stock	$ 38.00
100 mg	In stock	$ 53.00
200 mg	In stock	$ 63.00
500 mg	In stock	$ 81.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.55%

Purity: 99.37%

Purity: 99.33%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Norethindrone (Norethisterone) is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.
In vitro	Norethisterone, or, is a 19-nortestosterone derivative, that lacks a C19 methyl group and possesses C17 ethinyl substitution, and primarily displays progestational activity rather than androgenic activity and, to a lesser extent, has oestrogenic and anti-oestrogenic activity. [1] NET shows five- to eight-fold weaker progesterone receptor binding and transactivation activities than the Org 2058 (100%) and two-fold stronger than progesterone. Binding and transactivation activities of NET for androgen receptor (5α-dihydrotestosterone 100%) are 3.2 and 1.1%, respectively, for estrogen receptor none (estradiol 100%) and for glucocorticoid receptor below 1% (dexamethasone 100%). [2] Norethisterone (1 nM) inhibits serum-stimulated or oestradiol (0.1 nM)-induced proliferation of MCF-7 by 41% and 34%, respectively. [3] Norethisterone (50 nM) induces signi?cant effects on rat osteoblast proliferation, differentiation, and mineralization processes, mimicking the effects of estradiol, which is mediated by estrogen receptor. [4]
Cell Research	96 well plates are seeded with approximately 1000 MCF-7 cells per well in assay kit medium. Subsequently, the cells are incubated with medium containing charcoal/dextran treated serum for three days. The Norethisterone is then added alone to the wells and incubated for seven days. To mimic continuous combined HRT the cells are treated with an oestradiol (0.1 nM)/ Norethisterone combination for seven days. After incubation for seven days, cell proliferation is measured by using an ATP-chemosensitivity test. In brief, proliferation is quantified by measuring light emitted during the bioluminescence reaction of luciferine in the presence of ATP and luciferase.(Only for Reference)

Synonyms	Norethisterone
Molecular Weight	298.42
Formula	C20H26O2
CAS No.	68-22-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 56 mg/mL (187.7 mM)

Ethanol: 5 mg/mL (16.75 mM)

References and Literature

1. Schindler AE, et al. Maturitas, 2003, 46 Suppl 1, S7-S16. 2. Schoonen WG, et al. J Steroid Biochem Mol Biol, 2000, 74(4), 213-222. 3. Seeger H, et al. J Br Menopause Soc, 2003, 9(1), 36-38. 4. Enríquez J, et al. J Endocrinol. 2007 Jun;193(3):493-504. 5. Bain SD, et al. J Bone Miner Res, 1993, 8(2), 219-230. 6. Zeng X, Zhu S, Lu W, et al. Target identification among known drugs by deep learning from heterogeneous networks[J]. Chemical Science. 2020, 11(7): 1775-1797.

Citations

1. Zeng X, Zhu S, Lu W, et al. Target identification among known drugs by deep learning from heterogeneous networks. Chemical Science. 2020, 11(7): 1775-1797.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Bioactive Compounds Library Max Anti-Aging Compound Library Covalent Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library Bioactive Compound Library Drug-Fragment Library FDA-Approved & Pharmacopeia Drug Library FDA-Approved Drug Library

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Keywords

Norethindrone 68-22-4 Endocrinology/Hormones Others Progesterone Receptor Estrogen/progestogen Receptor NR3C3 Inhibitor inhibit Norethisterone inhibitor

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