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Oligomycin A

Catalog No. T6323 CAS 579-13-5

Synonyms: MCH 32

Oligomycin A (MCH 32) is an inhibitor of ATP synthase, inhibits oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitochondria.

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Oligomycin A, CAS 579-13-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 55.00
2 mg	In stock	$ 79.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 197.00
25 mg	In stock	Inquiry
50 mg	In stock	Inquiry
1 mL * 10 mM (in DMSO)	In stock	$ 136.00

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Purity: 99.86%

Purity: 99.84%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Oligomycin A (MCH 32) is an inhibitor of ATP synthase, inhibits oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitochondria.
Targets&IC50	F0F1-ATPase:1 μM(Ki)
In vitro	Oligomycin A is an inhibitor of ATP synthase, inhibits oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitochondria.Oligomycin A inhibits ATP synthase by blocking its proton channel (Fo subunit), which is necessary for oxidative phosphorylation of ADP to ATP. The inhibition of ATP synthesis by oligomycin A will significantly reduce electron flow through the electron transport chain; however, electron flow is not stopped completely due to a process known as proton leak or mitochondrial uncoupling. [1] In a group of cancer cells, Oligomycin at 100 ng/ml completely inhibits oxidative phosphorylation activity in 1 h and induces various levels of glycolysis gains by 6 h. [2] Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis. [3] Oligomycin inhibits mitochondrial respiration in melanoma, sensitizes melanoma cells to therapy, blocks the emergence of the slow-cycling, long-term tumor-maintaining melanoma cells. [4]
Cell Research	ATP and Oligomycin Dose-Response Growth Measurement. Cellular ATP changes are measured by CellTiter-Glo reagent. To measure oligomycin dose-response curves, the cells are plated in 96-well plates at about 400–500 cells/well in 100 μl of culture, dosed the next day, and grown for 4 additional days followed by assaying with Cell-Titer-Glo reagent. The dose-response curves are plotted with nonlinear regression analysis of GraphPad Prism.(Only for Reference)

Synonyms	MCH 32
Molecular Weight	791.06
Formula	C45H74O11
CAS No.	579-13-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (12.64 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Jastroch M, et al. Essays Biochem. 2010;47:53-67. 2. Hao W, et al. J Biol Chem, 2010, 285(17), 12647-12654. 3. Shchepina LA, et al. Oncogene, 2002, 21(53):8149-8157. 4. Roesch A, et al. Cancer Cell, 2013, 23(6), 811-825.

Citations

1. Jiang X C, Tu F H, Wei L Y, et al. Discovery of a Novel G-Quadruplex and Histone Deacetylase (HDAC) Dual-Targeting Agent for the Treatment of Triple-Negative Breast Cancer. Journal of Medicinal Chemistry. 2022

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Microbial Natural Product Library Anti-Cancer Compound Library Bioactive Compounds Library Max Natural Product Library Covalent Inhibitor Library Macrocyclic Compound Library Bioactive Compound Library NO PAINS Compound Library Anti-Infection Compound Library

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Keywords

Oligomycin A 579-13-5 Membrane transporter/Ion channel Microbiology/Virology ATPase Antibiotic Antifungal ATP Synthase Fungal MCH32 MCH 32 Inhibitor MCH-32 inhibit inhibitor

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