Shopping Cart
- Remove All
Your shopping cart is currently empty
PCO371
PCO371 (2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-) is an orally active full agonist of parathyroid hormone receptor 1. It has no effect on PTH type 2 receptor.
Catalog No. T16442Cas No. 1613373-33-3
Select Batch
Purity:99.25%
Contact us for more batch information
PCO371
Catalog No. T16442Alias 2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-Cas No. 1613373-33-3
PCO371 (2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-) is an orally active full agonist of parathyroid hormone receptor 1. It has no effect on PTH type 2 receptor.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $97 | In Stock | |
| 5 mg | $247 | In Stock | |
| 10 mg | $396 | In Stock | |
| 25 mg | $663 | In Stock | |
| 50 mg | $945 | In Stock | |
| 100 mg | $1,280 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $347 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "PCO371"
L-Thyroxine sodium
LT4 sodium, Levothyroxine sodium, L-T4 sodium
T2235555-03-8
L-Thyroxine sodium (LT4 sodium), the major hormone derived from the thyroid gland, is the agonist of Thyroid hormone receptor alpha and beta.
- $47
Size
QTY
Carbimazole
Athyromazole, Carbimazol, Neomercazole
T095222232-54-8
Carbimazole (Athyromazole) is an Imidazolium thyroid antagonist, which is rapidly transformed into MMI in vivo and can be converted into methidazole in vitro, and can be used in the study of Graves' disease.
- $29
Size
QTY
Liothyronine sodium
3,3',5-Triiodo-L-thyronine sodium, Triostat, T3 Sodium salt, Sodium L-3,3',5-triiodothyronine, Cytomel
T166955-06-1
Liothyronine Sodium is the sodium salt form of liothyronine, a synthetic form of the levorotatory isomer of the naturally occurring thyroid hormone triiodothyronine (T3). Liothyronine sodium (3,3',5-Triiodo-L-thyronine sodium) binds to nuclear thyroid receptors which then bind to thyroid hormone response elements of target genes. As a result, liothyronine sodium induces gene expression that is required for normal growth and development. Liothyronine sodium is more potent and has a more rapid action than thyroxine (T4).
- $47
Size
QTY
2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE
BisOPP-A
T867224038-68-4
2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE is targets the thyroid stimulating hormone receptor (human)
- $33
Size
QTY
Liothyronine
Cited
Tresitope, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, Triiodothyronine, L-3,3',5-Triiodothyronine, 3,3',5-Triiodo-L-thyronine, Lyothyronine
T16536893-02-3
Liothyronine (Tresitope) is an active form of thyroid hormone, binding to β1 thyroid hormone receptor (TRβ1), and activates its activity.
- $36
Size
QTY
Cited2-Thiouracil
Thiouracil, Deracil
T1310141-90-2
2-Thiouracil (Deracil) is a thiolated uracil derivative that is a known anti-hyperthyroid agent.
- $29
Size
QTY
L-Thyroxine
Levothyroxine, NSC 36397, T4
T086451-48-9
L-Thyroxine (NSC 36397) is the major hormone derived from the thyroid gland. L-Thyroxine (NSC 36397) is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. L-Thyroxine (NSC 36397) is released from thyroglobulin by proteolysis and secreted into the blood. L-Thyroxine (NSC 36397) is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
- $31
Size
QTY
Resmetirom
VIA-3196, MGL3196
T3595920509-32-6
Resmetirom (VIA-3196) is a highly selective thyroid hormone receptor β (THR-β) agonist.
- $33
Size
QTY
Tiratricol
3,3',5-Triiodothyroacetic acid
T160451-24-1
Tiratricol (3,3',5-Triiodothyroacetic acid) is a metabolite of T3 and T4 thyroid hormones; promoted for hyperlipidemia, localized lipodystrophy, and obesity. Tiratricol has been used in trials studying the treatment of Allan-Herndon-Dudley Syndrome.
- $29
Size
QTY
Propylthiouracil
Pseudocapsaicin, NSC 6498, NSC 70461, 6-n-Propylthiouracil, 6-Propyl-2-thiouracil
T130951-52-5
Propylthiouracil (6-n-Propylthiouracil) is a thyroid peroxidase inhibitor and also a 5' -deiodinase inhibitor.
- $33
Size
QTY
Methimazole
Tapazole, Thiamazole
T084060-56-0
Methimazole (Thiamazole) is an antithyroid compound with significant hepatotoxicity and is often used in the study of hyperthyroidism.
- $37
Size
QTY
DS08210767
T111012376334-75-5In house
DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with an IC50 of 90 nM.
- $129
Size
QTY
Product Introduction
Bioactivity
Chemical Properties
| Description | PCO371 (2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-) is an orally active full agonist of parathyroid hormone receptor 1. It has no effect on PTH type 2 receptor. |
| In vitro | In COS-7 cells expressing hPTHR1, PCO371 causes cAMP production (EC50: 2.4?μM). 2.5 μM in COS-7 cells transfected with hPTHR1-delNT, and also enhances the phospholipase C activity (EC50, 17?μM)[1]. |
| Alias | 2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl- |
| Molecular Weight | 635.65 |
| Formula | C29H32F3N5O6S |
| Cas No. | 1613373-33-3 |
Storage & Solubility Information
| Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 120 mg/mL (188.78 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy PCO371 | purchase PCO371 | PCO371 cost | order PCO371 | PCO371 chemical structure | PCO371 in vitro | PCO371 formula | PCO371 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.