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PF-05186462

PF-05186462
PF-05186462 (PF-05150122) is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.
Catalog No. T8711Cas No. 1235406-03-7
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Purity:99.37%
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PF-05186462

Catalog No. T8711Cas No. 1235406-03-7
PF-05186462 (PF-05150122) is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.
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Pack SizePriceAvailabilityQuantity
1 mg$133In Stock
5 mg$302In Stock
10 mg$453In Stock
25 mg$747In Stock
50 mg$1,050In Stock
1 mL x 10 mM (in DMSO)$389In Stock
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Product Introduction

Bioactivity
Description
PF-05186462 (PF-05150122) is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.
Targets&IC50
Nav1.7 (human):21 nM (IC50)
AliasPF-05150122
Chemical Properties
Molecular Weight531.89
FormulaC19H10ClF4N5O3S2
Cas No.1235406-03-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 11 mg/mL (20.68 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8801 mL9.4004 mL18.8009 mL94.0044 mL
5 mM0.3760 mL1.8801 mL3.7602 mL18.8009 mL
10 mM0.1880 mL0.9400 mL1.8801 mL9.4004 mL
20 mM0.0940 mL0.4700 mL0.9400 mL4.7002 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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