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Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cytochrome P450 system is minimal, reducing the risk of drug-drug interactions.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 34.00 | |
10 mg | In stock | $ 54.00 | |
25 mg | In stock | $ 76.00 | |
50 mg | In stock | $ 98.00 | |
100 mg | In stock | $ 171.00 | |
200 mg | In stock | $ 239.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 54.00 |
Description | Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cytochrome P450 system is minimal, reducing the risk of drug-drug interactions. |
Targets&IC50 | HMG-CoA:5.8 nM |
In vivo | Pitavastatin inhibits the progression of arterial atherosclerosis by blocking the synthesis of thromboxane and suppressing the migration or proliferation of vascular smooth muscle induced by angiotensin II, thereby stabilizing atherosclerotic plaques. It significantly reduces the levels of intracellular and synthesized cholesteryl esters. Moreover, pitavastatin enhances the extracellular expression of LDL receptors and increases the binding of LDL to LDL receptors. Compared to simvastatin and atorvastatin, pitavastatin is more effective in inducing the expression of LDL receptor mRNA. |
Synonyms | P-872441, nisvastatin, itavastatin, Pitavastatin hemicalcium, NK-104 |
Molecular Weight | 880.98 |
Formula | C50H46CaF2N2O8 |
CAS No. | 147526-32-7 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 44.1 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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Pitavastatin calcium 147526-32-7 Apoptosis Autophagy Metabolism Mitophagy HMG-CoA Reductase Endogenous Metabolite P-872441 NK104 HMG-CoA Reductase (HMGCR) P 872441 inhibit nisvastatin Pitavastatin P872441 itavastatin Inhibitor Pitavastatin hemicalcium NK 104 NK-104 hemicalcium NK-104 Mitochondrial Autophagy inhibitor