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Pitavastatin

Pitavastatin
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Pitavastatin

Catalog No. T7072Cas No. 147511-69-1
Pitavastatin (NK-104) is a potent inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase, effectively inhibiting cholesterol synthesis from acetic acid in HepG2 cells with an IC50 of 5.8 nM. It also induces hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptors and exhibits therapeutic activities such as anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective, and reno-protective effects.
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Pack SizePriceAvailabilityQuantity
5 mg$970In Stock
25 mg$1,520In Stock
50 mg$1,980In Stock
1 mL x 10 mM (in DMSO)$37In Stock
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Product Introduction

Bioactivity
Description
Pitavastatin (NK-104) is a potent inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase, effectively inhibiting cholesterol synthesis from acetic acid in HepG2 cells with an IC50 of 5.8 nM. It also induces hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptors and exhibits therapeutic activities such as anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective, and reno-protective effects.
In vitro
Pitavastatin inhibits the growth of a panel of ovarian cancer cells, including those likely representing HGSOC, with IC50 values of 0.4-5 μM in monolayers and 0.6-4 μM in spheroids [4]. At 1 μM for 48 hours, Pitavastatin induces apoptosis in Ovcar-8 and Ovcar-3 cells, increasing the activity of caspases-3, -7, -8, and -9, and results in PARP cleavage in Ovcar-8 cells, as evidenced by Western Blot analysis [1, 4].
In vivo
In 4-week-old female NCR Nu/Nu nude mice bearing Ovcar-4 tumors, Pitavastatin (administered at a dose of 59 mg/kg; orally (p.o.); twice daily for 28 days) is able to significantly induce tumor regression[4].
AliasNK104, NK 104, NK-104
Chemical Properties
Molecular Weight421.46
FormulaC25H24FNO4
Cas No.147511-69-1
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 80 mg/mL (94.91 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3727 mL11.8635 mL23.7270 mL118.6352 mL
5 mM0.4745 mL2.3727 mL4.7454 mL23.7270 mL
10 mM0.2373 mL1.1864 mL2.3727 mL11.8635 mL
20 mM0.1186 mL0.5932 mL1.1864 mL5.9318 mL
50 mM0.0475 mL0.2373 mL0.4745 mL2.3727 mL

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