Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 30.00 | |
25 mg | In stock | $ 44.00 | |
50 mg | In stock | $ 64.00 | |
100 mg | In stock | $ 93.00 | |
500 mg | In stock | $ 228.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor. |
In vitro | Quinoclamine induces the differentiation of U-937 cells into macrophage-like cells. Quinoclamine inhibits NF-κB activities in HepG2 cells (IC50: 1.7 μM). Quinoclamine inhibits induced NF-κB activities in lung and breast cancer cell lines. Quinoclamine affects the expression levels of genes involved in cell cycle or apoptosis. Quinoclamine down-regulates the expressions of UDP glucuronosyltransferase genes involved in phase II drug metabolism. Quinoclamine (1-4 μM; 30 minutes ) inhibits endogenous NF-κB activity in HepG2 cells through the inhibition of IκB-α phosphorylation and p65 translocation [1][2]. |
Molecular Weight | 207.61 |
Formula | C10H6ClNO2 |
CAS No. | 2797-51-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (1204.18 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Quinoclamine 2797-51-5 NF-Κb NF-κB Nuclear factor-κB derivative inhibit Inhibitor Nuclear factor-kappaB naphthoquinone inhibitor