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R 59-022
R 59-022 (DKGI-I) is a diacylglycerol kinase (DGK) inhibitor and a 5-HT Receptor antagonist that blocks filovirus internalization in host cells. R 59-022 activates protein kinase C (PKC), inhibits intestinal smooth muscle contractility, and enhances O2- production induced by 1-oleoyl-2-acetylglycerol.
Catalog No. T16709Cas No. 93076-89-2
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R 59-022
Catalog No. T16709Alias DKGI-I, Diacylglycerol kinase inhibitor ICas No. 93076-89-2
R 59-022 (DKGI-I) is a diacylglycerol kinase (DGK) inhibitor and a 5-HT Receptor antagonist that blocks filovirus internalization in host cells. R 59-022 activates protein kinase C (PKC), inhibits intestinal smooth muscle contractility, and enhances O2- production induced by 1-oleoyl-2-acetylglycerol.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $32 | In Stock | |
| 5 mg | $72 | In Stock | |
| 10 mg | $128 | In Stock | |
| 25 mg | $298 | In Stock | |
| 50 mg | $497 | In Stock | |
| 100 mg | $853 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | R 59-022 (DKGI-I) is a diacylglycerol kinase (DGK) inhibitor and a 5-HT Receptor antagonist that blocks filovirus internalization in host cells. R 59-022 activates protein kinase C (PKC), inhibits intestinal smooth muscle contractility, and enhances O2- production induced by 1-oleoyl-2-acetylglycerol. |
| Targets&IC50 | EBOV GP:~2 µM |
| In vitro | Vero cells were treated with increasing concentrations of R 59-022 and exposed for 4 hours to MLV pseudotypes encoding LacZ and bearing EBOV GP or VSV-G in the presence of the drug. R 59-022 blocked an entry step specific to EBOV GP. Vero cells were treated with increasing concentrations of R 59-022 and exposed to VLPs bearing EBOV GP or VSV G in the presence of the drug for 3 h. By CCF2-AM staining and flow cytometry analysis, R 59-022 dose-dependent decrease in entry by the VLPs harboring the EBOV GP , IC50: ~2 µM. [5] |
| Alias | DKGI-I, Diacylglycerol kinase inhibitor I |
| Molecular Weight | 459.58 |
| Formula | C27H26FN3OS |
| Cas No. | 93076-89-2 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (108.79 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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