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RITA

Catalog No. T1798   CAS 213261-59-7
Synonyms: NSC 652287, RITA (NSC 652287)

RITA (NSC-652287)(NSC-652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 interaction.

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RITA Chemical Structure
RITA, CAS 213261-59-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 30.00
2 mg In stock $ 38.00
5 mg In stock $ 61.00
10 mg In stock $ 97.00
25 mg In stock $ 198.00
50 mg In stock $ 363.00
100 mg In stock $ 535.00
200 mg In stock $ 752.00
500 mg In stock $ 1,150.00
1 mL * 10 mM (in DMSO) In stock $ 82.00
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Purity: 98.49%
Purity: 97.76%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description RITA (NSC-652287)(NSC-652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 interaction.
Targets&IC50 p53dN:1.5 nM (Kd)
Kinase Assay The inhibition profile of cabozantinib against a broad panel of 270 human kinases is determined using luciferase-coupled chemiluminescence,?33P-phosphoryl transfer, or AlphaScreen technology. Recombinant human full-length, glutathione?S-transferase tag, or histidine tag fusion proteins are used, and half maximal inhibitory concentration (IC50) values are determined by measuring phosphorylation of peptide substrate poly (Glu, Tyr) at ATP concentrations at or below the?Km?for each respective kinase. The mechanism of kinase inhibition is evaluated using the AlphaScreen Assay by determining the IC50?values over a range of ATP concentrations.
Cell Research Examination to assess susceptibility of cells to RITA (0.1 nM - 1 mM) is done using the XTT assay. Cells are inoculated into 96-well flat-bottom plates at a density of 1500 cells per well and incubated for 24 hours at 37 °C in a humidified 5% CO2 5% air atmosphere. Serial concentrations of RITA in DMSO are added to the wells, and sensitivity is determined 48 hours after the addition of RIT(Only for Reference)
Synonyms NSC 652287, RITA (NSC 652287)
Molecular Weight 292.37
Formula C14H12O3S2
CAS No. 213261-59-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 29.2 mg/mL (100 mM)

Ethanol: 7.3 mg/mL (25 mM)

TargetMolReferences and Literature

1. Rivera MI, et al. Biochem Pharmacol. 1999, 57(11), 1283-1295. 2. Nieves-Neira W, et al. Mol Pharmacol. 1999, 56(3), 478-484. 3. Issaeva N, et al. Nat Med. 2004, 10(12), 1321-1328. 4. Ma T, et al. Biochem Biophys Res Commun. 2012, 417(3), 931-937. 5. Saha MN, et al. PLoS One. 2012, 7(1), e30215.

TargetMolCitations

1. Fu Y, Liu Y, Wen T, et al. Real-time imaging of RNA polymerase I activity in living human cells. Journal of Cell Biology. 2022, 222(1): e202202110.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Tyrosine Kinase Inhibitor Library Anti-Cancer Metabolism Compound Library Anti-Pancreatic Cancer Compound Library Inhibitor Library Bioactive Lipid Compound Library DNA Damage & Repair Compound Library Ubiquitination Compound Library Apoptosis Compound Library Pyroptosis Compound Library

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Keywords

RITA 213261-59-7 Apoptosis Autophagy DNA Damage/DNA Repair p53 DNA Alkylator/Crosslinker Mdm2 MDM-2/p53 inhibit NSC-652287 NSC 652287 RITA (NSC 652287) NSC652287 Inhibitor inhibitor

 

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