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RO2959 Hydrochloride

🥰Excellent
Catalog No. T8867Cas No. 1219927-22-6
Alias RO2959 HCl

RO2959 Hydrochloride (RO2959 HCl) is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2.

RO2959 Hydrochloride

RO2959 Hydrochloride

🥰Excellent
Purity: 97.42%
Catalog No. T8867Alias RO2959 HClCas No. 1219927-22-6
RO2959 Hydrochloride (RO2959 HCl) is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2.
Pack SizePriceAvailabilityQuantity
1 mg$79In Stock
5 mg$173In Stock
10 mg$256In Stock
25 mg$397In Stock
50 mg$581In Stock
100 mg$768In Stock
1 mL x 10 mM (in DMSO)$197In Stock
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Purity:97.42%
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Product Introduction

Bioactivity
Description
RO2959 Hydrochloride (RO2959 HCl) is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2.
Targets&IC50
CRAC channel:402 nM
In vitro
RO2959 is a potent SOCE inhibitor that blocked an IP3-dependent current in CRAC-expressing RBL-2H3 cells and CHO cells stably expressing human Orai1 and Stim1, as well as SOCE in human primary CD4+ T cells triggered by either TCR stimulation or thapsigargin treatment. RO2959 completely inhibited cytokine production as well as T cell proliferation mediated by TCR stimulation or MLR (mixed lymphocyte reaction).
AliasRO2959 HCl
Chemical Properties
Molecular Weight463.93
FormulaC21H20ClF2N5OS
Cas No.1219927-22-6
SmilesCl.Cc1cnc(s1)N1CCC(C)=C(C1)c1cnc(NC(=O)c2c(F)cccc2F)cn1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 10 mg/mL (21.55 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1555 mL10.7775 mL21.5550 mL107.7749 mL
5 mM0.4311 mL2.1555 mL4.3110 mL21.5550 mL
10 mM0.2155 mL1.0777 mL2.1555 mL10.7775 mL
20 mM0.1078 mL0.5389 mL1.0777 mL5.3887 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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