Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RO2959 Hydrochloride (RO2959 HCl) is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 135.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 428.00 | |
25 mg | In stock | $ 686.00 | |
50 mg | In stock | $ 969.00 | |
100 mg | In stock | $ 1,280.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 329.00 |
Description | RO2959 Hydrochloride (RO2959 HCl) is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2. |
Targets&IC50 | CRAC channel:402 nM |
In vitro | RO2959 is a potent SOCE inhibitor that blocked an IP3-dependent current in CRAC-expressing RBL-2H3 cells and CHO cells stably expressing human Orai1 and Stim1, as well as SOCE in human primary CD4+ T cells triggered by either TCR stimulation or thapsigargin treatment. RO2959 completely inhibited cytokine production as well as T cell proliferation mediated by TCR stimulation or MLR (mixed lymphocyte reaction). |
Synonyms | RO2959 HCl |
Molecular Weight | 463.93 |
Formula | C21H20ClF2N5OS |
CAS No. | 1219927-22-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (21.55 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
RO2959 Hydrochloride 1219927-22-6 Immunology/Inflammation Membrane transporter/Ion channel Metabolism Calcium Channel IL Receptor Interleukin RO-2959 Hydrochloride IP3 SOCE RO 2959 Hydrochloride Ca2+ release-activated Ca2+ channels Interleukin Related inhibit IL-2 Stim1 CRAC Channel anti-proliferation RO 2959 Calcium release-activated channels T-cell RO-2959 Orai1 heart RO2959 Inhibitor failure RO2959 HCl inhibitor