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ROC-325

Catalog No. T16777   CAS 1859141-26-6

ROC-325 is an effective and orally active inhibitor of autophagy with anticancer activity. ROC-325 induces renal cell carcinoma apoptosis and exhibits favorable selectivity.

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ROC-325 Chemical Structure
ROC-325, CAS 1859141-26-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 48.00
2 mg In stock $ 68.00
5 mg In stock $ 97.00
10 mg In stock $ 167.00
25 mg In stock $ 337.00
50 mg In stock $ 547.00
100 mg In stock $ 789.00
500 mg In stock $ 1,630.00
1 mL * 10 mM (in DMSO) In stock $ 119.00
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Purity: 99.26%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ROC-325 is an effective and orally active inhibitor of autophagy with anticancer activity. ROC-325 induces renal cell carcinoma apoptosis and exhibits favorable selectivity.
In vitro ROC-325 (5 μM) leads to the formation of LC3B punctae and a robust increase in LC3B levels in both A498 and 786-0 RCC cells. ROC-325 promotes a dose-dependent increase in LC3B expression in a manner that correlated with a corresponding increase in the levels of p62 and cathepsin D. ROC-325 inhibits cells growth with IC50 values of 4.9 μM, 11 μM, 4.6 μM, 5.4 μM, 7.4 μM, 11 μM, 8.2 μM, 5.8 μM, 5.0 μM, 11 μM, 8.4 μM and 6.0 μM for A498, A549, CFPAC-1, COLO-205, DLD-1, IGROV-1, MCF-7, MiaPaCa-2, NCI-H69, PC-3, RL and UACC-62 cells, respectively. ROC-325 induces the deacidification of lysosomes, accumulation of autophagosomes, and disrupted autophagic flux[1].
In vivo In mice bearing 786-0 RCC xenografts, ROC-325 (25, 40, and 50 mg/kg; oral) leads to significant, dose-dependent inhibition of disease progression and inhibits autophagy in vivo[1].
Molecular Weight 503.06
Formula C28H27ClN4OS
CAS No. 1859141-26-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (59.64 mM), sonification is recommended.

H2O: 0.8 mg/mL (1.59 mM), sonification is recommended.

TargetMolReferences and Literature

1. Carew JS, et al. Disruption of Autophagic Degradation with ROC-325 Antagonizes Renal Cell Carcinoma Pathogenesis. Clin Cancer Res. 2017 Jun 1;23(11):2869-2879.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Bioactive Compound Library Orally Active Compound Library Inhibitor Library Bioactive Compounds Library Max Anti-Cancer Compound Library

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Keywords

ROC-325 1859141-26-6 Apoptosis Autophagy anticancer inhibit ROC325 ROC 325 Autophagosomes cathepsin-D lysosomes oral Inhibitor inhibitor

 

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