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SBI-0206965

Catalog No. T2128 CAS 1884220-36-3

Synonyms: SBI0206965

SBI-0206965 is a potent, selective and cell-permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.

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SBI-0206965, CAS 1884220-36-3

Pack Size	Availability	Price/USD
2 mg	In stock	$ 38.00
5 mg	In stock	$ 61.00
10 mg	In stock	$ 101.00
25 mg	In stock	$ 177.00
50 mg	In stock	$ 288.00
100 mg	In stock	$ 448.00
1 mL * 10 mM (in DMSO)	In stock	$ 66.00

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Purity: 98.86%

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Description	SBI-0206965 is a potent, selective and cell-permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.
Targets&IC50	ULK2:711 nM, ULK1:108 nM
In vitro	In HEK293T transfected with WT or KI Myc-tagged ULK1 and WT Vps34, SBI-0206965 inhibits Ser249 phosphorylation of overexpressed Vps34 and Beclin1 Ser15 phosphorylation. SBI-0206965 suppresses autophagy induced by mTOR inhibition in A549 cells, and prevents ULK1-dependent cell survival in WT MEFs. In addition, SBI-0206965 also synergizes with mTOR inhibition to induce cancer cell death. [1]

Synonyms	SBI0206965
Molecular Weight	489.32
Formula	C21H21BrN4O5
CAS No.	1884220-36-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL

References and Literature

1. Elokdah H, et al. J Med Chem. 2004, 47(14), 3491-3494. 3. Zhang H, Cui Z, Cheng D, et al. RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis[J]. Autophagy . 2020

Citations

1. Zhang H, Cui Z, Cheng D, et al. RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis. Autophagy. 2021 Oct;17(10):3030-3047 2. Qiu W Q, Pan R, Tang Y, et al. Lychee seed polyphenol inhibits Aβ-induced activation of NLRP3 inflammasome via the LRP1/AMPK mediated autophagy induction. Biomedicine & Pharmacotherapy. 2020, 130: 110575.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Highly Selective Inhibitor Library Inhibitor Library Apoptosis Compound Library Autophagy Compound Library Anti-Aging Compound Library Target-Focused Phenotypic Screening Library Bioactive Compound Library Bioactive Compounds Library Max NO PAINS Compound Library

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Keywords

SBI-0206965 1884220-36-3 Apoptosis Autophagy SBI 0206965 inhibit Inhibitor Unc-51 like kinase SBI0206965 ULK inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.