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SC99

Catalog No. T8719 CAS 882290-02-0

SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes.SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activities

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SC99, CAS 882290-02-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 80.00
5 mg	In stock	$ 189.00
10 mg	In stock	$ 292.00
25 mg	In stock	$ 560.00
50 mg	In stock	$ 788.00
100 mg	In stock	$ 1,120.00
1 mL * 10 mM (in DMSO)	In stock	$ 223.00

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Purity: 99.68%

Biological Description

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Description

In vitro

SC99 inhibited the phosphorylation of JAK2 and STAT3 in human platelets but had no effects on the phosphorylation of AKT, p65 or Src, all of which are involved in platelet activation.?SC99 inhibited human platelet aggregation induced by collagen and thrombin in a dose-dependent manner.?SC99 inhibited thrombin-induced P-selectin expression and fibrinogen binding to single platelets.?Moreover, SC99 inhibited platelet spreading on fibrinogen and clot retraction mediated by outside-in signaling.?SC99 inhibited platelet aggregation in mice but it did not significantly prolong the bleeding time.?SC99 inhibited platelet activation and aggregation as a STAT3 inhibitor.?This agent can be developed as a promising treatment for thrombotic disorders.

Molecular Weight	336.15
Formula	C15H8Cl2FN3O
CAS No.	882290-02-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 82 mg/mL (243.94 mM), Sonification is recommended.

References and Literature

1. Zhuan Xu, et at. A novel STAT3 inhibitor negatively modulates platelet activation and aggregation. Acta Pharmacol Sin. 2017 May;38(5):651-659. 2. Zubin Zhang, et al. A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway. Oncotarget. 2016 Feb 23;7(8):9296-308.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library JAK-STAT Compound Library Epigenetics Compound Library Kinase Inhibitor Library Covalent Inhibitor Library Anti-Prostate Cancer Compound Library Anti-Liver Cancer Compound Library Bioactive Compounds Library Max Reprogramming Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SC99 882290-02-0 Angiogenesis Apoptosis Chromatin/Epigenetic JAK/STAT signaling Stem Cells JAK STAT orally ERK c-Src ATP-binding phosphorylation platelet AKT Janus kinase activation SC-99 anti-myeloma mTOR anti-thrombotic Inhibitor myeloma pocket multiple aggregation OPM2 SC 99 inhibit inhibitor

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