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Search Results for " anti-myeloma "

Targets

33

Compounds

2

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T8719 SC99 Apoptosis , JAK , STAT
SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes.SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activiti...
T10981 DCZ0415 Apoptosis , Others , NF-κB
DCZ0415 induces antimyeloma activity in vitro, in vivo and in primary cells of drug-resistant myeloma patients. DCZ0415 is a potent TRIP13 inhibitor that can impair the repair of non-homologous end junctions and inhibit ...
T9918 Daratumumab Others
Daratumumab is a human monoclonal antibody that targets CD38 a cell surface protein that is overexpressed on multiple myeloma MM) cells.
T6800 CCF642 AC1LYELL Others
CCF642 (AC1LYELL) is a novel PDI-inhibiting compound with antimyeloma activity.
T2345 PTC-209 PTC209,PTC 209 BMI-1 , Autophagy
PTC-209 is a potent and selective BMI-1 inhibitor.
T3661 Citarinostat ACY241,HDAC-IN-2 HDAC
ACY-241, also known as Citarinostat (ACY241), is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon oral administration, ACY-241 inhibits the activ...
T6178 PTC-209 hydrobromide PTC-209 HBr BMI-1 , Autophagy
PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in irreversible reduction of cancer-initiating cells (CICs).
T12644L (S)-Thalidomide (S)-(-)-Thalidomide Apoptosis
(S)-Thalidomide ((S)-(-)-Thalidomide) is the S-isomer of Thalidomide with immunomodulatory, anti-inflammatory, anticancer, anti-angiogenic and pro-apoptotic activities, and is used in the study of leprosy erythema nodosu...
T35390 Magrolimab Hu5F9-G4,Magrolimab (anti-CD47) Others
Magrolimab (Hu5F9-G4) is a humanized anti-CD47 IgG4 monoclonal antibody that exhibits its antitumor activity by blocking CD47 and binds primarily to the N-terminal pyroglutamate of CD47, and can be used in combination wi...
T35386 Elotuzumab Elotuzumab (anti-SLAMF7),BMS 901608,PDL 063,HuLuc 63 Others
Elotuzumab(HuLuc 63) is a monoclonal antibody that targets the SLAMF7 receptor.Elotuzumab is a compound that directly activates NK cells and induces antibody-dependent cytotoxicity, and can be used in combination with le...
T76794 Ulocuplumab BMS 936564,MDX 1338 Apoptosis , CXCR
Ulocuplumab (BMS-936564) is a fully human anti-CXCR4 IgG4 antibody.Ulocplumab exhibits antitumor activity in acute myeloid leukemia (AML), non-Hodgkin's lymphoma (NHL), and multiple myeloma transplantation models.Ulocplu...
T28805 SLM6 NSC-107517,NSC 107517,Sangivamycin-Like Molecule 6,SLM 6,SLM-6
SLM6, an inhibitor of cyclin-dependent kinase-9 (CDK9), exhibits potent anti-multiple myeloma activity.
T63906 HGGPPS-IN-2
hGGPPS-IN-2 is an analogue of C-2 substituted thienopyrimidinyl bisphosphonates (C2-ThP-BPs) and is a potent inhibitor of human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-2 targets multiple myeloma (MM) ce...
T73485 BT-GSI
BT-GSI is a γ-secretase inhibitor (GSI) and a bone-targeted Notch inhibitor. BT-GSI has dual anti-myeloma and anti-resorptive properties, which can be used for the research of multiple myeloma and associated bone disease...
T61792 HDAC6-IN-10
HDAC6-IN-10 is a potent and specific HDAC6 inhibitor, exhibiting an IC50 value of 0.73 nM. It demonstrates remarkable selectivity towards HDAC6, with a selectivity range of 144 to 10,941-fold over other HDAC isoforms. Fu...
T11141 E64FC26 Others
E64FC26 is a potent protein disulfide isomerase (PDI) family pan-inhibitor with antitumor activity, inhibits PDIA1, PDIA3, PDIA4, TXNDC5 and PDIA6, and can be used in the study of multiple myeloma and pancreatic cancer.
T36625 LSD1/HDAC6-IN-1 LSD1/HDAC6-IN-1
LSD1/HDAC6-IN-1 is an orally active compound that functions as a dual inhibitor, targeting lysine specific demethylase 1 (LSD1) and histone deacetylase 6 (HDAC6). This compound demonstrates promising anti-tumor activity ...
T39812 (E/Z)-E64FC26 (E/Z)-E64FC26
(E/Z)-E64FC26 is a mixture complex comprising E-E64FC26 and Z-E64FC26. E-E64FC26 is a highly potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50 values of 1.9, 20.9, 25.9, 16.3, and 25.4 μM ag...
T69323 Dexamethasone sodium succinate
Dexamethasone sodium succinate is the acetate salt form of dexamethasone, which is a synthetic glucocorticoid; it combines high anti-inflammatory effects with low mineralocorticoid activity. At high doses (e.g. 40 mg), i...
T77903 Belantamab mafodotin Belantamab mafodotin-blm,GSK2857916
Belantamab mafodotin (GSK2857916) is a conjugate of a humanized, targeted monoclonal antibody directed against the B cell maturation antigen (BCMA) and the cytotoxic agent McMMAF, exhibiting anti-myeloma activity [1] [2]...
T76677 Dacetuzumab
Dacetuzumab (SGN-40) is a humanized IgG1 , anti-CD40 monoclonal antibody with anti-lymphoma activity. Dacetuzumab kills tumor cells via immune effector functions (antibody-dependent cellular cytotoxicity and phagocytosis...
T61945 HGGPPS-IN-1
HGGPPS-IN-1 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). HGGPPS-IN-1 has an effective inhibitory effect on human geranyl geranyl pyrophosphate synthase (hGGPPS). HGGPPS-IN-1 can ...
T77091 Modakafusp alfa
Modakafusp alfa (TAK-573) is a humanized, anti-CD38 IgG4 monoclonal antibody fused to 2 attenuated IFNα2b molecules. Modakafusp alfa can be used in the research of multiple myeloma [1] .
T36761 KRAS inhibitor-10
KRAS inhibitor-10 (WO2021005165 A1, compound 11) is a potent and selective inhibitor of RAS proteins, with a specific focus on KRAS proteins. This orally active anti-cancer agent demonstrates strong efficacy in cancer re...
T61313 Antitumor agent-70
Antitumor agent-70 (compound 8b) is a highly potent multi-targeted kinase inhibitor, particularly targeting c-Kit. It demonstrates remarkable anti-tumor activity and the ability to induce cell apoptosis. This compound al...
T77084 Mezagitamab
Mezagitamab (TAK-079) is a IgG1λ anti- CD38 monoclonal antibody. Mezagitamab depletes tumor cells expressing CD38 through antibody and complement dependent cytotoxicity. Mezagitamab has potential application in relapsed/...
T79478 Anti-inflammatory agent 45 Apoptosis
Compound 2v (Anti-inflammatory agent 45) demonstrates anticancer properties with direct inhibitory impacts on the proliferation of various blood malignancies, such as leukemia, lymphoma, and myeloma cell lines. It induce...
T15158 Dolastatin 15 DLS 15 Others
Dolastatin 15, a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the anti-tubulin agent Dolastatin 10. Dolastatin 15 can be used as an ADC cytotoxin and it induces c...
T77139 Pavurutamab
Pavurutamab (AMG-701) is a bispecific T cell engager molecule that anti- CD3 and anti- B cell maturation antigens ( BCMA ). Pavurutamab has an extended half-life based on Pacanalotamab . The Fc of Pavurutamab is coupled ...
T79523 HDAC6-IN-18 HDAC
HDAC6-IN-18 (Compound 4), an irreversible and selective HDAC6 isoform inhibitor, exhibits potent anti-multiple myeloma effects. It demonstrates HDAC6 inhibitory activity with IC50 values of 0.17, 0.7, and 0.42 μM in RPMI...
T69821 AMP423
AMP423 is a naphthyl derivative of 2-cyanoaziridine-1-carboxamide with structural similarity to the pro-oxidant anti-tumor agent imexon. AMP423 was active in SCID mice bearing 8226/S myeloma and SU-DHL-6 B-cell lymphoma ...
T76729 Lucatumumab
Lucatumumab (HCD122) is a fully human anti-CD40 antagonist monoclonal antibody, which blocks CD40/CD40L-mediated signaling. Lucatumumab efficiently mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and cleara...
T62907 TAS-117 hydrochloride
TAS-117 hydrochloride is a selective, potent, orally active allosteric Akt inhibitor, acting on Akt1 (IC50: 4.8 nM), Akt2 (IC50: 1.6 nM) and Akt3 (IC50: 44 nM). TAS-117 hydrochloride stimulates anti-myeloma activity, enh...

Compounds

SC99
T8719
Synonym:
Target: Apoptosis, JAK, STAT
DCZ0415
T10981
Synonym:
Target: Apoptosis, Others, NF-κB
Daratumumab
T9918
Synonym:
Target: Others
CCF642
T6800
Synonym: AC1LYELL
Target: Others
PTC-209
T2345
Synonym: PTC209,PTC 209
Target: BMI-1, Autophagy
Citarinostat
T3661
Synonym: ACY241,HDAC-IN-2
Target: HDAC
PTC-209 hydrobromide
T6178
Synonym: PTC-209 HBr
Target: BMI-1, Autophagy
(S)-Thalidomide
T12644L
Synonym: (S)-(-)-Thalidomide
Target: Apoptosis
Magrolimab
T35390
Synonym: Hu5F9-G4,Magrolimab (anti-CD47)
Target: Others
Elotuzumab
T35386
Synonym: Elotuzumab (anti-SLAMF7),BMS 901608,PDL 063,HuLuc 63
Target: Others
Ulocuplumab
T76794
Synonym: BMS 936564,MDX 1338
Target: Apoptosis, CXCR
SLM6
T28805
Synonym: NSC-107517,NSC 107517,Sangivamycin-Like Molecule 6,SLM 6,SLM-6
Target:
hGGPPS-IN-2
T63906
Synonym:
Target:
BT-GSI
T73485
Synonym:
Target:
HDAC6-IN-10
T61792
Synonym:
Target:
E64FC26
T11141
Synonym:
Target: Others
LSD1/HDAC6-IN-1
T36625
Synonym: LSD1/HDAC6-IN-1
Target:
(E/Z)-E64FC26
T39812
Synonym: (E/Z)-E64FC26
Target:
Dexamethasone sodium succinate
T69323
Synonym:
Target:
Belantamab mafodotin
T77903
Synonym: Belantamab mafodotin-blm,GSK2857916
Target:
Dacetuzumab
T76677
Synonym:
Target:
hGGPPS-IN-1
T61945
Synonym:
Target:
Modakafusp alfa
T77091
Synonym:
Target:
KRAS inhibitor-10
T36761
Synonym:
Target:
Antitumor agent-70
T61313
Synonym:
Target:
Mezagitamab
T77084
Synonym:
Target:
Anti-inflammatory agent 45
T79478
Synonym:
Target: Apoptosis
Dolastatin 15
T15158
Synonym: DLS 15
Target: Others
Pavurutamab
T77139
Synonym:
Target:
HDAC6-IN-18
T79523
Synonym:
Target: HDAC
AMP423
T69821
Synonym:
Target:
Lucatumumab
T76729
Synonym:
Target:
TAS-117 hydrochloride
T62907
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T3398 Icaritin Anhydroicaritin,Cycloicaritin Apoptosis , JAK , STAT , Autophagy
Icaritin (Anhydroicaritin) has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation. Ica...
TN3870 Iriflophenone 2-O-Rhamnoside Dimethylmatairesinol Others
Dimethylmatairesinol can reduce the amount of Immunoglobulin E (IgE) secreted by human myeloma U266 cells, it has potential as an anti-allergic agent. Dimethylmatairesinol also exhibits significant cytotoxicity against t...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-00130 SLAMF2 Protein, Human, Recombinant (hFc & His) Human Human Cells
CD48 antigen, also known as B-lymphocyte activation marker BLAST-1, BCM1 surface antigen, Leukocyte antigen MEM-102, TCT.1, CD48, BCM1,and BLAST1, CD48 contains one Ig-like C2-type domain and one Ig-like V-type domain, b...
TargetMol