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SR 11302
Catalog No. T23384Cas No. 160162-42-5
SR 11302 is an inhibitor of activator protein-1 (AP-1).
SR 11302
Catalog No. T23384Cas No. 160162-42-5
SR 11302 is an inhibitor of activator protein-1 (AP-1).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $89 | 1-2 weeks | |
| 5 mg | $147 | 1-2 weeks | |
| 10 mg | $228 | 1-2 weeks | |
| 25 mg | $396 | 1-2 weeks | |
| 50 mg | $653 | 1-2 weeks | |
| 100 mg | $987 | 2-4 weeks | |
| 1 mL x 10 mM (in DMSO) | $473 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SR 11302 is an inhibitor of activator protein-1 (AP-1). |
| In vitro | SR 11302 can inhibit the growth of breast cancer cell line T-47D, the lung cancer line Calu-6, and HeLa cells. SR 11302 had very little effect on either the proliferation or the differentiation of HL-60, fresh APL, and NB4 cells[2]. |
| In vivo | In an AP-1-luciferase transgenic mouse carcinogenesis model, SR11302 significantly inhibits both AP-1 activations in 7,12-dimethyl benz(a)anthracene-initiated mouse skin and 12-O-tetradecanoylphorbol-13-acetate-induced papilloma formation[3]. |
| Molecular Weight | 376.53 |
| Formula | C26H32O2 |
| Cas No. | 160162-42-5 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (132.79 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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