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SR3335

SR3335
SR3335 (ML 176) is a selective inverse agonist of RORα that competitively inhibits the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).
Catalog No. T5160Cas No. 293753-05-6
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Purity:99.77%
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SR3335

Catalog No. T5160Cas No. 293753-05-6
SR3335 (ML 176) is a selective inverse agonist of RORα that competitively inhibits the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$31In Stock
5 mg$72In Stock
10 mg$128In Stock
25 mg$258In Stock
50 mg$478In Stock
100 mg$689In Stock
1 mL x 10 mM (in DMSO)$79In Stock
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Product Introduction

Bioactivity
Description
SR3335 (ML 176) is a selective inverse agonist of RORα that competitively inhibits the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).
Targets&IC50
RORα:220 nM(ki)
AliasML 176
Chemical Properties
Molecular Weight405.34
FormulaC13H9F6NO3S2
Cas No.293753-05-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 30 mg/mL
DMSO: 50 mg/mL (123.35 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4671 mL12.3353 mL24.6706 mL123.3532 mL
5 mM0.4934 mL2.4671 mL4.9341 mL24.6706 mL
10 mM0.2467 mL1.2335 mL2.4671 mL12.3353 mL
20 mM0.1234 mL0.6168 mL1.2335 mL6.1677 mL
50 mM0.0493 mL0.2467 mL0.4934 mL2.4671 mL
100 mM0.0247 mL0.1234 mL0.2467 mL1.2335 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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