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SSD114 HCl
Catalog No. T4522Cas No. 2319790-02-6
SSD114 is a novel GABAB receptor positive allosteric modulator.
SSD114 HCl
Catalog No. T4522Cas No. 2319790-02-6
SSD114 is a novel GABAB receptor positive allosteric modulator.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $32 | In Stock | |
| 2 mg | $46 | In Stock | |
| 5 mg | $80 | In Stock | |
| 10 mg | $122 | In Stock | |
| 25 mg | $198 | In Stock | |
| 50 mg | $316 | In Stock | |
| 100 mg | $538 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $68 | In Stock |
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Purity:99.03%
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Product Introduction
Bioactivity
Chemical Properties
| Description | SSD114 is a novel GABAB receptor positive allosteric modulator. |
| In vitro | In conditions containing 10 μM GABA, 25 μM SSD114 hydrochloride significantly increased the level of [35S]GTPγS activation induced by GABA alone to approximately 170% of basal levels.SSD114 hydrochloride (15 or 30 μM) caused a shift in the GABA concentration-response curve to the left and at the highest concentration slightly increased the maximal stimulatory effect of GABA. In the co-presence of 15 and 30 μM SSD114 hydrochloride, the EC50 of GABA was reduced by 2-fold and 2.5-fold, respectively, while the maximal stimulatory effect (Emax) was enhanced only at the 30 μM concentration to 161 ± 5.09% of the basal value [1]. |
| In vivo | SSD114 hydrochloride pretreatment significantly shortened the onset time of the loss-of-orientation reflex (LORR) [F(5,30)=4.55, P<0.005]. Follow-up analyses showed that the onset time of LORR was significantly shorter in the group of mice that received pretreatment at doses equal to or higher than 10 mg/kg SSD114 hydrochloride compared to the control group. In addition, SSD114 hydrochloride pretreatment prolonged the duration of LORR [F(5,30)=4.81, P<0.005]. Follow-up analysis indicated that the LORR duration was significantly prolonged in the group of mice receiving 10 and 100 mg/kg SSD114 hydrochloride pretreatment compared to the control group [1]. |
| Molecular Weight | 387.83 |
| Formula | C18H21ClF3N3O |
| Cas No. | 2319790-02-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (116.03 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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