Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 48.00 | |
5 mg | In stock | $ 79.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 222.00 | |
50 mg | In stock | $ 372.00 | |
100 mg | In stock | $ 538.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 79.00 |
Description | SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues. |
Targets&IC50 | 15-PGDH:0.1 nM(Ki), 15-PGDH:1.5 nM |
In vitro | In Vaco-503 cells, SW033291 (2.5 μM) decreases cellular 15-PGDH enzyme activity by 85%.[1] |
In vivo | In mice receiving a bone marrow transplant, SW033291 (10 mg/kg, i.p.) promotes hematopoietic recovery. In mouse models of colon and liver injury, SW033291 (10 mg/kg, i.p.) reduces the levels of colitis-associated inflammatory cytokines, protects mice from colitis, and promotes liver regeneration. [1] |
Kinase Assay | Fluorescence anisotropy (FP) ligand displacement assay: All components are dissolved in buffer of composition 50 mM HEPES pH 7.4, 150 mM NaCl and 0.5 mM CHAPS with final concentrations of BRD 2/3/4 75 nM, fluorescent ligand 5 nM. 10 μL of this reaction mixture is added using a micro multidrop to wells containing 100 nL of various concentrations of I-BET151 or DMSO vehicle (1% final) in Greiner 384 well Black low volume microtitre plate and equilibrated in the dark for 60 minutes at room temperature. Fluorescence anisotropy is read in Envision (lex = 485 nm, lEM = 530 nm; Dichroic = 505 nM). |
Molecular Weight | 412.59 |
Formula | C21H20N2OS3 |
CAS No. | 459147-39-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 41.3 mg/mL (100 mM)
Ethanol: 8.3 mg/mL (20 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SW033291 459147-39-8 Metabolism Dehydrogenase knockout PGE2 15-PGDH Peripheral prostaglandin bone inhibit neutrophil SW-033291 SW 033291 hematopoietic 15-Hydroxyprostaglandin dehydrogenase marrow Inhibitor inhibitor