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Se-Methylselenocysteine

Se-Methylselenocysteine
Se-Methylselenocysteine (Se-MSC) is a potent chemopreventive agent in many test systems and has been shown to inhibit tumor promotion and induce apoptosis.
Catalog No. T7727Cas No. 26046-90-2
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Purity:99.49%
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Se-Methylselenocysteine

Catalog No. T7727Cas No. 26046-90-2
Se-Methylselenocysteine (Se-MSC) is a potent chemopreventive agent in many test systems and has been shown to inhibit tumor promotion and induce apoptosis.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$39In Stock
10 mg$68In Stock
25 mg$139In Stock
50 mg$222In Stock
100 mg$332In Stock
200 mg$498In Stock
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Product Introduction

Bioactivity
Description
Se-Methylselenocysteine (Se-MSC) is a potent chemopreventive agent in many test systems and has been shown to inhibit tumor promotion and induce apoptosis.
In vitro
Se-Methylselenocysteine displayed strong inhibitory effects on cell proliferation and viability of SKOV-3 cells in dose and time dependent manners and induced apoptosis. Pretreatment of cells with the caspase inhibitors (z-VAD-fmk and DEVD-CHO) prevented Se-Methylselenocysteine-induced apoptosis. In late stage of apoptosis, p18kDa fragment of Bax was generated with the down-regulation of the expressions of survivin, X-linked inhibitor of apoptosis protein, and human inhibitor of apoptosis protein 1 following Se-Methylselenocysteine treatment. Pre-treatments of z-VAD-fmk and the calpain inhibitor, calpeptin inhibited Bax cleavage. Taken together, the chemopreventive effects of Se-Methylselenocysteine may be related in part to the caspase-3 activation, the down-regulation of IAP family proteins, and Bax cleavage mediated by caspase-dependent calpain activation[2].
In vivo
AD mice are treated with Se-Methylselenocysteine (0.75 mg kg-1 BW per day) in their drinking water for 10 months. Results reveal that Se-Methylselenocysteine 1) reduces oxidative stress and neuro-inflammation; 2) modulates the distribution and levels of several metal ions; 3) decreases amyloid-β peptide (Aβ) generation by inhibiting the expression of its precursor protein APP and β-secretase (BACE1); and 4) attenuates tau hyperphosphorylation and neurofibrillary tangles (NFT) formation via promoting protein phosphatase 2A (PP2A) activity, thereby preserving synaptic proteins and neuron activities and finally improving spatial learning and memory deficits in AD model mice[4].
AliasSe MSC, SeMCys, MSeC, Se-MSC, SeMSC
Chemical Properties
Molecular Weight182.08
FormulaC4H9NO2Se
Cas No.26046-90-2
Storage & Solubility Information
Storagekeep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 83.33 mg/mL (457.66 mM)
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM5.4921 mL27.4605 mL54.9209 mL274.6046 mL
5 mM1.0984 mL5.4921 mL10.9842 mL54.9209 mL
10 mM0.5492 mL2.7460 mL5.4921 mL27.4605 mL
20 mM0.2746 mL1.3730 mL2.7460 mL13.7302 mL
50 mM0.1098 mL0.5492 mL1.0984 mL5.4921 mL
100 mM0.0549 mL0.2746 mL0.5492 mL2.7460 mL

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