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Search Results for " chemopreventive "

Targets

13

Compounds

48

Natural Products

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T40253 3-Phenylpropyl isothiocyanate Others
3-Phenylpropyl isothiocyanate exhibits a potent inhibitory effect on N-nitrosomethyl-benzylamine (NMBA) tumorigenesis, thereby displaying strong chemopreventive properties [1] [2].
T0314 Hexylresorcinol 4-Hexylresorcinol Apoptosis , Tyrosinase , Antibacterial , Parasite
Hexylresorcinol (4-Hexylresorcinol) is a substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections.
T1872 Fenretinide 4-HPR,MK-4016,4-hydroxy(phenyl)retinamide Retinoid Receptor , Autophagy
Fenretinide (4-HPR) is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities.
T13602 CDDO-2P-Im CDDO-2-P-Im Others
CDDO-2P-Im shows chemopreventive effect and reduces the size and severity of the lung tumors in the mouse lung cancer model.
T13603 CDDO-3P-Im Necroptosis
CDDO-3P-Im is an orally active inhibitor of necroptosis with chemopreventive effects. CDDO-3P-Im can be used in studies about ischemia/reperfusion.
T6743 (E/Z)-4-Hydroxytamoxifen Afimoxifene,4-Hydroxytamoxifen Estrogen Receptor/ERR , Estrogen/progestogen Receptor
(E/Z)-4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.
T6157 Devimistat CPI-613,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid Apoptosis , Dehydrogenase , Mitochondrial Metabolism
Devimistat (6,8-Bis(benzylthio)octanoic acid) , a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial metabolism. It has potent...
T0153 Oltipraz NSC 347901,RP 35972 HIF/HIF Prolyl-Hydroxylase , HIV Protease , Reverse Transcriptase , Nrf2 , HIF
Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H: quin...
T30228 Avicenol A
Avicenol A is a cancer chemopreventive agent.
T34745 Sulforemate
Sulforemate is a phase II enzyme inducer for chemopreventive activities.
T23661 Agamanone
Agamanone is an anticancer agent. It also has antioxidant and chemopreventive properties.
T40560 Benzyl selenocyanate
Benzyl selenocyanate is a chemopreventive agent that effectively inhibits chemically induced tumors at both initiation and postinitiation stages in animal models. It acts as a potent inhibitor of DNA (cytosine-5)-methylt...
T78587 Se-Methylselenocysteine hydrochloride Methylselenocysteine hydrochloride,Se-Methylseleno-L-cysteine hydrochloride Beta-Secretase
Se-Methylselenocysteine hydrochloride, a precursor to Methylselenol, exhibits significant cancer chemopreventive and antioxidant activities. It is orally bioavailable and promotes apoptosis [1] [2].
Cat No. Product Name Synonyms Targets
TN1046 Murrayone Others
Murrayone, a coumarin-containing compound derived from M. paniculata, stands out as the most bioactive substance within this species, primarily due to its unique pharmacological attributes that notably suppress cancer me...
T5372 L-SelenoMethionine L-(+)-Selenomethionine Apoptosis , Amino Acids and Derivatives , Endogenous Metabolite
L-SelenoMethionine (L-(+)-Selenomethionine) is a naturally occurring amino acid. It promotes cell cycle progression and elevates the expression of the antioxidant enzymes thioredoxin reductase, glutathione reductase.
TN1025 3,29-O-Dibenzoyloxykarounidiol Others
3,29-O-Dibenzoyloxykarounidiol is a natural product with regulate blood sugar level, has potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) induced by tumor promoter 12-O-tetradecanoylphorbol-13-aceta...
TN6742 β-Damascone Damascone Others
β-Damascone are a series of closely related chemical compounds that are components of a variety of essential oils. The damascones belong to a family of chemicals known as rose ketones, which also includes damascenones an...
T6670 Silymarin Silybin B SARS-CoV
Silymarin (Silybin B) (Silybin B) is a polyphenolic flavonoid that extracts from the milk thistle or seeds of Silybum marianum. It is used in the prevention and treatment of liver diseases.
T7727 Se-Methylselenocysteine Se MSC,SeMCys,MSeC,Se-MSC,SeMSC BCL , IAP , Caspase
Se-Methylselenocysteine (Se-MSC) is a potent chemopreventive agent in many test systems and has been shown to inhibit tumor promotion and induce apoptosis.
TQ0212 Glucoraphanin Antioxidant , Reactive Oxygen Species
Glucoraphanin, the precursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, has antioxidant activity.
T1059 Retinyl palmitate Retinol palmitate,Vitamin A palmitate,Retinyl (Vitamin A) Palmitate Others , Endogenous Metabolite
Retinyl palmitate (Vitamin A palmitate) is a naturally-occurring phenyl analogue of retinol, with potential antineoplastic and chemopreventive activities.
T3399 Psoralidin Others , Estrogen/progestogen Receptor , Reactive Oxygen Species , Lipoxygenase , Gamma-secretase , Akt , COX , Antibacterial
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive properties.
T4S0590 Columbin Phospholipase , COX , Parasite
1. Columbin has anti-inflammatory activity. 2. Columbin has chemopreventive ability against human colon cancer. 3. Columbin inhibits PLA2 hydrolysis of ghost RBC in a dose-dependent fashion.
T3909 Pulsatilla saponin D Hederacolchiside A,SB365 Apoptosis , Others
Pulsatilla saponin D (Hederacolchiside A) has exhibited potential beneficial effects as a chemopreventive agent for critical health conditions including cancer, and it inhibits cell growth via cell cycle arrest and apopt...
T3411 Curdione (+)-Curdione P450
Curdione ((+)-Curdione) inhibits CYP3A4 activity and the production of prostaglandin E2. Curdione inhibits proliferation of MCF-7 cells by inducing apoptosis. Curdione may be a candidate for anti-inflammatory and Y chemo...
T1558 Resveratrol trans-Resveratrol,SRT 501 Apoptosis , Mitophagy , IκB/IKK , Lipoxygenase , Sirtuin , COX , NADPH , DNA/RNA Synthesis , Nrf2 , Antibacterial , Antibiotic , Autophagy , Antifungal
Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autop...
TN1244 3'-Demethylnobiletin LDL , NF-κB , Integrin , Lipoxygenase , DNA/RNA Synthesis
3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle arrest, induce apoptosis, and profoundly modulate signaling ...
T3342 Xanthohumol Apoptosis , Others , Influenza Virus , COX , Acyltransferase , HSV
Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows ...
T5429 Theaflavin 3,3'-digallate 8-Gingerol,TFDG Virus Protease , Antioxidant , HIV Protease , HSV
Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregul...
T1633 β-Carotene Carotaben,Beta-Carotene,Provitamin A Apoptosis , ROS , Endogenous Metabolite
β-Carotene (Provitamin A) is a naturally-occurring retinol (vitamin A) precursor obtained from certain fruits and vegetables with potential antineoplastic and chemopreventive activities. As an anti-oxidant, beta carotene...
T1082 Benzyl isothiocyanate Benzoylthiocarbimide,Isothiocyanic Acid Benzoyl Ester Apoptosis , Antibacterial , Antibiotic
Benzyl isothiocyanate (Benzoylthiocarbimide) (BITC) is an isothiocyanate originally found in cruciferous vegetables. It shows immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiog...
TN1088 3,​5,​6,​7,​8,​3',​4'-​Heptemthoxyflavone 3,3',4',5,6,7,8-heptamethoxyflavone Others
3,5,6,7,8,3',4'-Heptemthoxyflavone has neuroprotective, chemopreventive, anti-allergic, anti-inflammatory, immunomodulatory, anti-aging and photoprotective effects; it inhibits collagenase activity and induces type I pro...
TN2330 Phenethyl ferulate Caffeic Acid 3-Methyl Phenethyl Ester Lipoxygenase , COX
Phenethyl ferulate (Caffeic Acid 3-Methyl Phenethyl Ester) has chemopreventive properties against chemically induced colon carcinogenesis. It enhances apoptosis in azoxymethane induced colon tumors. It shows inhibitory a...
T3403 Glabridin Q-100692,KB-289522,LS-176045 Reactive Oxygen Species , Tyrosinase , GABA Receptor , Antibacterial , PPAR
Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on...
T3S0013 Ethyl trans-caffeate Ethyl caffeate,Caffeic Acid Ethyl Ester Others
1. Ethyl trans-caffeate (Caffeic Acid Ethyl Ester) has anti-inflammatory activity. 2. Ethyl trans-caffeate may as a promising natural compound for future application in chronic liver disease. 3. Ethyl trans-caffeate is a...
TN2807 21-Episerratenediol Others
21-Episerratenediol may be as a potent cancer chemopreventive agent.
TN5022 Silyamandin Others
Silyamandin may have antihepatotoxic and chemopreventive activities.
TMA0033 5'-Demethylaquillochin NADPH-oxidase
5'-Demethylaquillochin and its isomer from the dichloromethane extract of E. cavaleriei have potential as chemopreventive agents through induction of detoxification enzymes. 5'-Demethylaquillochin exhibits the most poten...
TN5329 Epitulipinolide diepoxide
Epitulipinolide diepoxide has antioxidative and chemopreventive activities in skin melanoma cells, can significantly inhibit the proliferation of melanoma cells, it possesses cytotoxic activity against KB cells.
TN4496 Marginatoxin Caspase , Fas/FasL
Marginatoxin may be a promising chemopreventive agent for treating hepatocellular carcinoma, it induces human hepatoma BEL-7402 cells apoptosis in vitro and in vivo via activation of Fas/FasL-mediated apoptotic pathway.
TN3446 Aristolactam FI Others
Aristolactam FI shows platelet aggregation inhibitory activity.It is a potential cancer chemotherapeutic and chemopreventive agent.
TN3852 Dihydrolicoisoflavone Antifection
Dihydrolicoisoflavone A possesses weaker anti-H. pylori activity, it may be useful chemopreventive agents for peptic ulcer or gastric cancer in H. pylori-infected individuals.
TN6651 Picrasidine Q
Picrasidine Q has the capacity of anti-cell transformation and anti-cancer, it might be a chemopreventive and chemotherapeutic agent by direct targeting FGFR2 and inhibiting cell proliferation of ESCC cells.
TN1832 Kanzonol C Others , NF-κB , Tyrosinase
Kanzonol C has antimicrobial activity, it also shows potent PTP1B inhibitory activity (IC50 value of 0.31-0.97uM). Kanzonol C has chemopreventive activity,it shows the inhibition of matrix metalloproteinase (MMP)-2 secre...
TN1302 6,8-Diprenylorobol Others , HIV Protease , Antifection
6,8-Diprenylorobol possesses weaker anti-H. pylori activity, it may be a useful chemopreventive agent for peptic ulcer or gastric cancer in H. pylori-infected individuals.
TN1538 Curzerenone Caspase , Antifection
Curzerenone holds great promise for use in chemopreventive and chemotherapeutic strategies, it has slightly effective against E. coli (IZ = 10.8 ± 0.52).
T82301 Gluconapin potassium
Gluconapin potassium, a precursor to the potent anti-cancer isothiocyanate sulforaphane [1], serves as an important chemical compound in chemopreventive applications.
TN6591 Cannabisin B
Cannabisin B possesses considerable antiproliferative activity and that it may be utilised as a promising chemopreventive agent against hepatoblastoma disease. It induces autophagic cell death by inhibiting the AKT/mTOR ...
TN4273 Isocoronarin D Others
Isocoronarin D is a main active ingredient for inducing death of the tested cancer cells, it possesses a wide anti-cancer capability. Isocoronarin D may have potential chemopreventive activity, it can activate antioxidan...
TN2047 Pendulone Antifection
Pendulone could be a valuable chemopreventive agent, it shows strong inhibition on the effect of the cell cycle induced by TPA and shows potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test.
TN4420 Latifolin 檀木 IL Receptor , IκB/IKK , TNF , NOS , NF-κB , COX , Nrf2 , Prostaglandin Receptor , Antifection , Autophagy
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latifolin displays potent anticarcinogenic phase II marker enzyme,...
TN3655 Cimiside E ERK , TNF , ROS , Akt , PI3K , PKC , PPAR
Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC are involved in this effect.Cimiside E may b...
TN3366 Ailanthoidol IL Receptor , NOS , COX , Prostaglandin Receptor , PPAR
Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potential as a chemopreventive agent against tumor promotion. Ailan...
TN2928 Pygenic acid A 3-Epicorosolic acid
3-Epicorosolic acid has a potent inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induction, it has potential anti-inflammatory activities as well as cancer chemopreventive activity.3-Epicorosolic acid show...
TN3070 4beta-Hydroxywithanolide E PARP , HSP , NF-κB , COX
4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progression and develop into a dietary chemopreventive agent, it...
TN3806 Dehydroglyasperin C ERK , IκB/IKK , p38 MAPK , TNF , NF-κB , Akt , COX , PI3K , NADPH , DNA/RNA Synthesis , Nrf2 , JNK , Autophagy
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neuroprotective activities, it has protectiv...
T80996 Theasaponin E1
Theasaponin E1 is a saponin derived from tea seeds, demonstrating antitumor potential in human tumor cell lines K562 and HL60. Additionally, it possesses quinone reductase (QR)-inducing activity, suggesting its efficacy ...
TN3348 (+)-Acuminatin Acuminatin PAFR
(+)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity against platelet aggregation with IC50 values of 108.5 and 90...
TN4291 Isofuranodiene IL Receptor , NOS
Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver diseases. Isofuranodiene has anticancer activity, by inhibiting...
TN4471 Lysicamine IL Receptor , Antifection
Lysicamine shows significant antioxidant capacity in the ORAC(FL) assay and it is active against S. epidermidis and C. dubliniensis, with MIC values in the range 12.5-100 microg mL(-1). Lysicamine has antimicrobial and a...
TN1783 Isolicoflavonol Lipid
Isolicoflavonol is a potential cancer chemopreventive agent.

Natural Products

Murrayone
TN1046
Synonym:
Target: Others
L-SelenoMethionine
T5372
Synonym: L-(+)-Selenomethionine
Target: Apoptosis, Amino Acids and Derivatives, Endogenous Metabolite
3,29-O-Dibenzoyloxykarounidiol
TN1025
Synonym:
Target: Others
β-Damascone
TN6742
Synonym: Damascone
Target: Others
Silymarin
T6670
Synonym: Silybin B
Target: SARS-CoV
Se-Methylselenocysteine
T7727
Synonym: Se MSC,SeMCys,MSeC,Se-MSC,SeMSC
Target: BCL, IAP, Caspase
Glucoraphanin
TQ0212
Synonym:
Target: Antioxidant, Reactive Oxygen Species
Retinyl palmitate
T1059
Synonym: Retinol palmitate,Vitamin A palmitate,Retinyl (Vitamin A) Palmitate
Target: Others, Endogenous Metabolite
Psoralidin
T3399
Synonym:
Target: Others, Estrogen/progestogen Receptor, Reactive Oxygen Species, Lipoxygenase, Gamma-secretase, Akt, COX, Antibacterial
Columbin
T4S0590
Synonym:
Target: Phospholipase, COX, Parasite
Pulsatilla saponin D
T3909
Synonym: Hederacolchiside A,SB365
Target: Apoptosis, Others
Curdione
T3411
Synonym: (+)-Curdione
Target: P450
Resveratrol
T1558
Synonym: trans-Resveratrol,SRT 501
Target: Apoptosis, Mitophagy, IκB/IKK, Lipoxygenase, Sirtuin, COX, NADPH, DNA/RNA Synthesis, Nrf2, Antibacterial, Antibiotic, Autophagy, Antifungal
3'-Demethylnobiletin
TN1244
Synonym:
Target: LDL, NF-κB, Integrin, Lipoxygenase, DNA/RNA Synthesis
Xanthohumol
T3342
Synonym:
Target: Apoptosis, Others, Influenza Virus, COX, Acyltransferase, HSV
Theaflavin 3,3'-digallate
T5429
Synonym: 8-Gingerol,TFDG
Target: Virus Protease, Antioxidant, HIV Protease, HSV
β-Carotene
T1633
Synonym: Carotaben,Beta-Carotene,Provitamin A
Target: Apoptosis, ROS, Endogenous Metabolite
Benzyl isothiocyanate
T1082
Synonym: Benzoylthiocarbimide,Isothiocyanic Acid Benzoyl Ester
Target: Apoptosis, Antibacterial, Antibiotic
3,​5,​6,​7,​8,​3',​4'-​Heptemthoxyflavone
TN1088
Synonym: 3,3',4',5,6,7,8-heptamethoxyflavone
Target: Others
Phenethyl ferulate
TN2330
Synonym: Caffeic Acid 3-Methyl Phenethyl Ester
Target: Lipoxygenase, COX
Glabridin
T3403
Synonym: Q-100692,KB-289522,LS-176045
Target: Reactive Oxygen Species, Tyrosinase, GABA Receptor, Antibacterial, PPAR
Ethyl trans-caffeate
T3S0013
Synonym: Ethyl caffeate,Caffeic Acid Ethyl Ester
Target: Others
21-Episerratenediol
TN2807
Synonym:
Target: Others
Silyamandin
TN5022
Synonym:
Target: Others
5'-Demethylaquillochin
TMA0033
Synonym:
Target: NADPH-oxidase
Epitulipinolide diepoxide
TN5329
Synonym:
Target:
Marginatoxin
TN4496
Synonym:
Target: Caspase, Fas/FasL
Aristolactam FI
TN3446
Synonym:
Target: Others
Dihydrolicoisoflavone
TN3852
Synonym:
Target: Antifection
Picrasidine Q
TN6651
Synonym:
Target:
Kanzonol C
TN1832
Synonym:
Target: Others, NF-κB, Tyrosinase
6,8-Diprenylorobol
TN1302
Synonym:
Target: Others, HIV Protease, Antifection
Curzerenone
TN1538
Synonym:
Target: Caspase, Antifection
Gluconapin potassium
T82301
Synonym:
Target:
Cannabisin B
TN6591
Synonym:
Target:
Isocoronarin D
TN4273
Synonym:
Target: Others
Pendulone
TN2047
Synonym:
Target: Antifection
Latifolin
TN4420
Synonym: 檀木
Target: IL Receptor, IκB/IKK, TNF, NOS, NF-κB, COX, Nrf2, Prostaglandin Receptor, Antifection, Autophagy
Cimiside E
TN3655
Synonym:
Target: ERK, TNF, ROS, Akt, PI3K, PKC, PPAR
Ailanthoidol
TN3366
Synonym:
Target: IL Receptor, NOS, COX, Prostaglandin Receptor, PPAR
Pygenic acid A
TN2928
Synonym: 3-Epicorosolic acid
Target:
4beta-Hydroxywithanolide E
TN3070
Synonym:
Target: PARP, HSP, NF-κB, COX
Dehydroglyasperin C
TN3806
Synonym:
Target: ERK, IκB/IKK, p38 MAPK, TNF, NF-κB, Akt, COX, PI3K, NADPH, DNA/RNA Synthesis, Nrf2, JNK, Autophagy
Theasaponin E1
T80996
Synonym:
Target:
(+)-Acuminatin
TN3348
Synonym: Acuminatin
Target: PAFR
Isofuranodiene
TN4291
Synonym:
Target: IL Receptor, NOS
Lysicamine
TN4471
Synonym:
Target: IL Receptor, Antifection
Isolicoflavonol
TN1783
Synonym:
Target: Lipid

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-00210 FGF-2 Protein, Mouse, Recombinant (His) Mouse E. coli
Basic fibroblast growth factor (bFGF), also known as FGF2, is a member of the fibroblast growth factor (FGF) family. It is a highly specific chemotactic and mitogenic factor for many cell types, appears to be involved in...
TMPY-00749 FGF-2 Protein, Human, Recombinant Human E. coli
Basic fibroblast growth factor (bFGF), also known as FGF2, is a member of the fibroblast growth factor (FGF) family. It is a highly specific chemotactic and mitogenic factor for many cell types, appears to be involved in...
TargetMol