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Cat No. | Product Name | Synonyms | Targets |
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T40253 | 3-Phenylpropyl isothiocyanate | Others | |
3-Phenylpropyl isothiocyanate exhibits a potent inhibitory effect on N-nitrosomethyl-benzylamine (NMBA) tumorigenesis, thereby displaying strong chemopreventive properties [1] [2]. | |||
T0314 | Hexylresorcinol | 4-Hexylresorcinol | Apoptosis , Tyrosinase , Antibacterial , Parasite |
Hexylresorcinol (4-Hexylresorcinol) is a substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections. | |||
T1872 | Fenretinide | 4-HPR,MK-4016,4-hydroxy(phenyl)retinamide | Retinoid Receptor , Autophagy |
Fenretinide (4-HPR) is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities. | |||
T13602 | CDDO-2P-Im | CDDO-2-P-Im | Others |
CDDO-2P-Im shows chemopreventive effect and reduces the size and severity of the lung tumors in the mouse lung cancer model. | |||
T13603 | CDDO-3P-Im | Necroptosis | |
CDDO-3P-Im is an orally active inhibitor of necroptosis with chemopreventive effects. CDDO-3P-Im can be used in studies about ischemia/reperfusion. | |||
T6743 | (E/Z)-4-Hydroxytamoxifen | Afimoxifene,4-Hydroxytamoxifen | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
(E/Z)-4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. | |||
T6157 | Devimistat | CPI-613,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid | Apoptosis , Dehydrogenase , Mitochondrial Metabolism |
Devimistat (6,8-Bis(benzylthio)octanoic acid) , a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial metabolism. It has potent... | |||
T0153 | Oltipraz | NSC 347901,RP 35972 | HIF/HIF Prolyl-Hydroxylase , HIV Protease , Reverse Transcriptase , Nrf2 , HIF |
Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H: quin... | |||
T30228 | Avicenol A | ||
Avicenol A is a cancer chemopreventive agent. | |||
T34745 | Sulforemate | ||
Sulforemate is a phase II enzyme inducer for chemopreventive activities. | |||
T23661 | Agamanone | ||
Agamanone is an anticancer agent. It also has antioxidant and chemopreventive properties. | |||
T40560 | Benzyl selenocyanate | ||
Benzyl selenocyanate is a chemopreventive agent that effectively inhibits chemically induced tumors at both initiation and postinitiation stages in animal models. It acts as a potent inhibitor of DNA (cytosine-5)-methylt... | |||
T78587 | Se-Methylselenocysteine hydrochloride | Methylselenocysteine hydrochloride,Se-Methylseleno-L-cysteine hydrochloride | Beta-Secretase |
Se-Methylselenocysteine hydrochloride, a precursor to Methylselenol, exhibits significant cancer chemopreventive and antioxidant activities. It is orally bioavailable and promotes apoptosis [1] [2]. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN1046 | Murrayone | Others | |
Murrayone, a coumarin-containing compound derived from M. paniculata, stands out as the most bioactive substance within this species, primarily due to its unique pharmacological attributes that notably suppress cancer me... | |||
T5372 | L-SelenoMethionine | L-(+)-Selenomethionine | Apoptosis , Amino Acids and Derivatives , Endogenous Metabolite |
L-SelenoMethionine (L-(+)-Selenomethionine) is a naturally occurring amino acid. It promotes cell cycle progression and elevates the expression of the antioxidant enzymes thioredoxin reductase, glutathione reductase. | |||
TN1025 | 3,29-O-Dibenzoyloxykarounidiol | Others | |
3,29-O-Dibenzoyloxykarounidiol is a natural product with regulate blood sugar level, has potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) induced by tumor promoter 12-O-tetradecanoylphorbol-13-aceta... | |||
TN6742 | β-Damascone | Damascone | Others |
β-Damascone are a series of closely related chemical compounds that are components of a variety of essential oils. The damascones belong to a family of chemicals known as rose ketones, which also includes damascenones an... | |||
T6670 | Silymarin | Silybin B | SARS-CoV |
Silymarin (Silybin B) (Silybin B) is a polyphenolic flavonoid that extracts from the milk thistle or seeds of Silybum marianum. It is used in the prevention and treatment of liver diseases. | |||
T7727 | Se-Methylselenocysteine | Se MSC,SeMCys,MSeC,Se-MSC,SeMSC | BCL , IAP , Caspase |
Se-Methylselenocysteine (Se-MSC) is a potent chemopreventive agent in many test systems and has been shown to inhibit tumor promotion and induce apoptosis. | |||
TQ0212 | Glucoraphanin | Antioxidant , Reactive Oxygen Species | |
Glucoraphanin, the precursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, has antioxidant activity. | |||
T1059 | Retinyl palmitate | Retinol palmitate,Vitamin A palmitate,Retinyl (Vitamin A) Palmitate | Others , Endogenous Metabolite |
Retinyl palmitate (Vitamin A palmitate) is a naturally-occurring phenyl analogue of retinol, with potential antineoplastic and chemopreventive activities. | |||
T3399 | Psoralidin | Others , Estrogen/progestogen Receptor , Reactive Oxygen Species , Lipoxygenase , Gamma-secretase , Akt , COX , Antibacterial | |
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive properties. | |||
T4S0590 | Columbin | Phospholipase , COX , Parasite | |
1. Columbin has anti-inflammatory activity. 2. Columbin has chemopreventive ability against human colon cancer. 3. Columbin inhibits PLA2 hydrolysis of ghost RBC in a dose-dependent fashion. | |||
T3909 | Pulsatilla saponin D | Hederacolchiside A,SB365 | Apoptosis , Others |
Pulsatilla saponin D (Hederacolchiside A) has exhibited potential beneficial effects as a chemopreventive agent for critical health conditions including cancer, and it inhibits cell growth via cell cycle arrest and apopt... | |||
T3411 | Curdione | (+)-Curdione | P450 |
Curdione ((+)-Curdione) inhibits CYP3A4 activity and the production of prostaglandin E2. Curdione inhibits proliferation of MCF-7 cells by inducing apoptosis. Curdione may be a candidate for anti-inflammatory and Y chemo... | |||
T1558 | Resveratrol | trans-Resveratrol,SRT 501 | Apoptosis , Mitophagy , IκB/IKK , Lipoxygenase , Sirtuin , COX , NADPH , DNA/RNA Synthesis , Nrf2 , Antibacterial , Antibiotic , Autophagy , Antifungal |
Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autop... | |||
TN1244 | 3'-Demethylnobiletin | LDL , NF-κB , Integrin , Lipoxygenase , DNA/RNA Synthesis | |
3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle arrest, induce apoptosis, and profoundly modulate signaling ... | |||
T3342 | Xanthohumol | Apoptosis , Others , Influenza Virus , COX , Acyltransferase , HSV | |
Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows ... | |||
T5429 | Theaflavin 3,3'-digallate | 8-Gingerol,TFDG | Virus Protease , Antioxidant , HIV Protease , HSV |
Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregul... | |||
T1633 | β-Carotene | Carotaben,Beta-Carotene,Provitamin A | Apoptosis , ROS , Endogenous Metabolite |
β-Carotene (Provitamin A) is a naturally-occurring retinol (vitamin A) precursor obtained from certain fruits and vegetables with potential antineoplastic and chemopreventive activities. As an anti-oxidant, beta carotene... | |||
T1082 | Benzyl isothiocyanate | Benzoylthiocarbimide,Isothiocyanic Acid Benzoyl Ester | Apoptosis , Antibacterial , Antibiotic |
Benzyl isothiocyanate (Benzoylthiocarbimide) (BITC) is an isothiocyanate originally found in cruciferous vegetables. It shows immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiog... | |||
TN1088 | 3,5,6,7,8,3',4'-Heptemthoxyflavone | 3,3',4',5,6,7,8-heptamethoxyflavone | Others |
3,5,6,7,8,3',4'-Heptemthoxyflavone has neuroprotective, chemopreventive, anti-allergic, anti-inflammatory, immunomodulatory, anti-aging and photoprotective effects; it inhibits collagenase activity and induces type I pro... | |||
TN2330 | Phenethyl ferulate | Caffeic Acid 3-Methyl Phenethyl Ester | Lipoxygenase , COX |
Phenethyl ferulate (Caffeic Acid 3-Methyl Phenethyl Ester) has chemopreventive properties against chemically induced colon carcinogenesis. It enhances apoptosis in azoxymethane induced colon tumors. It shows inhibitory a... | |||
T3403 | Glabridin | Q-100692,KB-289522,LS-176045 | Reactive Oxygen Species , Tyrosinase , GABA Receptor , Antibacterial , PPAR |
Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on... | |||
T3S0013 | Ethyl trans-caffeate | Ethyl caffeate,Caffeic Acid Ethyl Ester | Others |
1. Ethyl trans-caffeate (Caffeic Acid Ethyl Ester) has anti-inflammatory activity. 2. Ethyl trans-caffeate may as a promising natural compound for future application in chronic liver disease. 3. Ethyl trans-caffeate is a... | |||
TN2807 | 21-Episerratenediol | Others | |
21-Episerratenediol may be as a potent cancer chemopreventive agent. | |||
TN5022 | Silyamandin | Others | |
Silyamandin may have antihepatotoxic and chemopreventive activities. | |||
TMA0033 | 5'-Demethylaquillochin | NADPH-oxidase | |
5'-Demethylaquillochin and its isomer from the dichloromethane extract of E. cavaleriei have potential as chemopreventive agents through induction of detoxification enzymes. 5'-Demethylaquillochin exhibits the most poten... | |||
TN5329 | Epitulipinolide diepoxide | ||
Epitulipinolide diepoxide has antioxidative and chemopreventive activities in skin melanoma cells, can significantly inhibit the proliferation of melanoma cells, it possesses cytotoxic activity against KB cells. | |||
TN4496 | Marginatoxin | Caspase , Fas/FasL | |
Marginatoxin may be a promising chemopreventive agent for treating hepatocellular carcinoma, it induces human hepatoma BEL-7402 cells apoptosis in vitro and in vivo via activation of Fas/FasL-mediated apoptotic pathway. | |||
TN3446 | Aristolactam FI | Others | |
Aristolactam FI shows platelet aggregation inhibitory activity.It is a potential cancer chemotherapeutic and chemopreventive agent. | |||
TN3852 | Dihydrolicoisoflavone | Antifection | |
Dihydrolicoisoflavone A possesses weaker anti-H. pylori activity, it may be useful chemopreventive agents for peptic ulcer or gastric cancer in H. pylori-infected individuals. | |||
TN6651 | Picrasidine Q | ||
Picrasidine Q has the capacity of anti-cell transformation and anti-cancer, it might be a chemopreventive and chemotherapeutic agent by direct targeting FGFR2 and inhibiting cell proliferation of ESCC cells. | |||
TN1832 | Kanzonol C | Others , NF-κB , Tyrosinase | |
Kanzonol C has antimicrobial activity, it also shows potent PTP1B inhibitory activity (IC50 value of 0.31-0.97uM). Kanzonol C has chemopreventive activity,it shows the inhibition of matrix metalloproteinase (MMP)-2 secre... | |||
TN1302 | 6,8-Diprenylorobol | Others , HIV Protease , Antifection | |
6,8-Diprenylorobol possesses weaker anti-H. pylori activity, it may be a useful chemopreventive agent for peptic ulcer or gastric cancer in H. pylori-infected individuals. | |||
TN1538 | Curzerenone | Caspase , Antifection | |
Curzerenone holds great promise for use in chemopreventive and chemotherapeutic strategies, it has slightly effective against E. coli (IZ = 10.8 ± 0.52). | |||
T82301 | Gluconapin potassium | ||
Gluconapin potassium, a precursor to the potent anti-cancer isothiocyanate sulforaphane [1], serves as an important chemical compound in chemopreventive applications. | |||
TN6591 | Cannabisin B | ||
Cannabisin B possesses considerable antiproliferative activity and that it may be utilised as a promising chemopreventive agent against hepatoblastoma disease. It induces autophagic cell death by inhibiting the AKT/mTOR ... | |||
TN4273 | Isocoronarin D | Others | |
Isocoronarin D is a main active ingredient for inducing death of the tested cancer cells, it possesses a wide anti-cancer capability. Isocoronarin D may have potential chemopreventive activity, it can activate antioxidan... | |||
TN2047 | Pendulone | Antifection | |
Pendulone could be a valuable chemopreventive agent, it shows strong inhibition on the effect of the cell cycle induced by TPA and shows potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test. | |||
TN4420 | Latifolin | 檀木 | IL Receptor , IκB/IKK , TNF , NOS , NF-κB , COX , Nrf2 , Prostaglandin Receptor , Antifection , Autophagy |
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latifolin displays potent anticarcinogenic phase II marker enzyme,... | |||
TN3655 | Cimiside E | ERK , TNF , ROS , Akt , PI3K , PKC , PPAR | |
Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC are involved in this effect.Cimiside E may b... | |||
TN3366 | Ailanthoidol | IL Receptor , NOS , COX , Prostaglandin Receptor , PPAR | |
Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potential as a chemopreventive agent against tumor promotion. Ailan... | |||
TN2928 | Pygenic acid A | 3-Epicorosolic acid | |
3-Epicorosolic acid has a potent inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induction, it has potential anti-inflammatory activities as well as cancer chemopreventive activity.3-Epicorosolic acid show... | |||
TN3070 | 4beta-Hydroxywithanolide E | PARP , HSP , NF-κB , COX | |
4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progression and develop into a dietary chemopreventive agent, it... | |||
TN3806 | Dehydroglyasperin C | ERK , IκB/IKK , p38 MAPK , TNF , NF-κB , Akt , COX , PI3K , NADPH , DNA/RNA Synthesis , Nrf2 , JNK , Autophagy | |
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neuroprotective activities, it has protectiv... | |||
T80996 | Theasaponin E1 | ||
Theasaponin E1 is a saponin derived from tea seeds, demonstrating antitumor potential in human tumor cell lines K562 and HL60. Additionally, it possesses quinone reductase (QR)-inducing activity, suggesting its efficacy ... | |||
TN3348 | (+)-Acuminatin | Acuminatin | PAFR |
(+)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity against platelet aggregation with IC50 values of 108.5 and 90... | |||
TN4291 | Isofuranodiene | IL Receptor , NOS | |
Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver diseases. Isofuranodiene has anticancer activity, by inhibiting... | |||
TN4471 | Lysicamine | IL Receptor , Antifection | |
Lysicamine shows significant antioxidant capacity in the ORAC(FL) assay and it is active against S. epidermidis and C. dubliniensis, with MIC values in the range 12.5-100 microg mL(-1). Lysicamine has antimicrobial and a... | |||
TN1783 | Isolicoflavonol | Lipid | |
Isolicoflavonol is a potential cancer chemopreventive agent. |
Cat No. | Product Name | Species | Expression System |
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TMPY-00210 | FGF-2 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Basic fibroblast growth factor (bFGF), also known as FGF2, is a member of the fibroblast growth factor (FGF) family. It is a highly specific chemotactic and mitogenic factor for many cell types, appears to be involved in... | |||
TMPY-00749 | FGF-2 Protein, Human, Recombinant | Human | E. coli |
Basic fibroblast growth factor (bFGF), also known as FGF2, is a member of the fibroblast growth factor (FGF) family. It is a highly specific chemotactic and mitogenic factor for many cell types, appears to be involved in... |