store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19). At 10 μM, sulfaphenazole has been shown to inhibit endothelium-derived hyperpolarizing factor synthase, a CYP450 isozyme in the porcine coronary artery homologous to CYP2C8/9 that generates reactive oxygen species in coronary endothelial cells and modulates vascular tone and homeostasis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | In stock | $ 50.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 48.00 |
Description | Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19). At 10 μM, sulfaphenazole has been shown to inhibit endothelium-derived hyperpolarizing factor synthase, a CYP450 isozyme in the porcine coronary artery homologous to CYP2C8/9 that generates reactive oxygen species in coronary endothelial cells and modulates vascular tone and homeostasis. |
Targets&IC50 | CYP2C9:0.3 μM (Ki) |
Synonyms | Plisulfan, Raziosulfa, Depocid, Depotsulfonamide |
Molecular Weight | 314.36 |
Formula | C15H14N4O2S |
CAS No. | 526-08-9 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 0.5 mg/mL
DMSO: 50 mg/mL (159.05 mM)
You can also refer to dose conversion for different animals. More
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Sulfaphenazole 526-08-9 Metabolism Microbiology/Virology P450 Antibacterial Plisulfan inhibit Raziosulfa Bacterial Inhibitor Depocid Depotsulfonamide inhibitor