Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

TAK-441

Catalog No. T21325Cas No. 1186231-83-3
Alias TAK441

TAK-441 is an orally active inhibitor of Hedgehog signaling(IC50 = 4.4 nM) with potent antitumor activity. TAK-441 suppresses transcription factor Gli1 mRNA expression and tumor growth.

TAK-441

TAK-441

Purity: 98.79%
Catalog No. T21325Alias TAK441Cas No. 1186231-83-3
TAK-441 is an orally active inhibitor of Hedgehog signaling(IC50 = 4.4 nM) with potent antitumor activity. TAK-441 suppresses transcription factor Gli1 mRNA expression and tumor growth.
Pack SizePriceAvailabilityQuantity
1 mg$100In Stock
5 mg$247In Stock
10 mg$372In Stock
25 mg$668In Stock
50 mg$993In Stock
100 mg$1,490In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "TAK-441"

Select Batch
Purity:98.79%
Contact us for more batch information
Resource Download
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

Product Introduction

Bioactivity
Description
TAK-441 is an orally active inhibitor of Hedgehog signaling(IC50 = 4.4 nM) with potent antitumor activity. TAK-441 suppresses transcription factor Gli1 mRNA expression and tumor growth.
In vitro
TAK-441 (0.03 nM–1 μM) inhibits Gli1 mRNA in the tumor and skin with IC50s of 45.7 and 113 μg/ml, respectively[3]. In LNCaP cells, TAK-441 (0.5-500 nM) delays the castration-resistant progression without affecting androgen withdrawal-induced Shh up-regulation or cell viability[4].
In vivo
In ptc1+/-p53-/- mice, oral administration of TAK-441 (1-25 mg/kg) shows strong and dose-dependent antitumor activity. In BALB/c-nu/nu mice, oral administration of TAK-441 (10-100 mg/kg) shows favorable exposure and good oral absorption[4].
AliasTAK441
Chemical Properties
Molecular Weight576.56
FormulaC28H31F3N4O6
Cas No.1186231-83-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45 mg/mL (78.05 mM)
H2O: Insoluble
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7344 mL8.6721 mL17.3442 mL86.7212 mL
5 mM0.3469 mL1.7344 mL3.4688 mL17.3442 mL
10 mM0.1734 mL0.8672 mL1.7344 mL8.6721 mL
20 mM0.0867 mL0.4336 mL0.8672 mL4.3361 mL
50 mM0.0347 mL0.1734 mL0.3469 mL1.7344 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy TAK-441 | purchase TAK-441 | TAK-441 cost | order TAK-441 | TAK-441 chemical structure | TAK-441 in vivo | TAK-441 in vitro | TAK-441 formula | TAK-441 molecular weight