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TAK-441

TAK-441 is an orally active inhibitor of Hedgehog signaling(IC50 = 4.4 nM) with potent antitumor activity. TAK-441 suppresses transcription factor Gli1 mRNA expression and tumor growth.

Catalog No. T21325Cas No. 1186231-83-3

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Purity:98.79%

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COA HNMR HPLC

TAK-441

Catalog No. T21325Cas No. 1186231-83-3

TAK-441 is an orally active inhibitor of Hedgehog signaling(IC50 = 4.4 nM) with potent antitumor activity. TAK-441 suppresses transcription factor Gli1 mRNA expression and tumor growth.

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

Pack Size	Price	Availability
1 mg	$100	In Stock
5 mg	$247	In Stock
10 mg	$372	In Stock
25 mg	$668	In Stock
50 mg	$993	In Stock
100 mg	$1,490	In Stock

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Product Introduction

Bioactivity

Description	TAK-441 is an orally active inhibitor of Hedgehog signaling(IC50 = 4.4 nM) with potent antitumor activity. TAK-441 suppresses transcription factor Gli1 mRNA expression and tumor growth.
In vitro	TAK-441 (0.03 nM–1 μM) inhibits Gli1 mRNA in the tumor and skin with IC50s of 45.7 and 113 μg/ml, respectively[3]. In LNCaP cells, TAK-441 (0.5-500 nM) delays the castration-resistant progression without affecting androgen withdrawal-induced Shh up-regulation or cell viability[4].
In vivo	In ptc1+/-p53-/- mice, oral administration of TAK-441 (1-25 mg/kg) shows strong and dose-dependent antitumor activity. In BALB/c-nu/nu mice, oral administration of TAK-441 (10-100 mg/kg) shows favorable exposure and good oral absorption[4].
Alias	TAK441

Chemical Properties

Molecular Weight	576.56
Formula	C₂₈H₃₁F₃N₄O₆
Cas No.	1186231-83-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 45 mg/mL (78.05 mM)

H2O: Insoluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7344 mL	8.6721 mL	17.3442 mL	86.7212 mL
5 mM	0.3469 mL	1.7344 mL	3.4688 mL	17.3442 mL
10 mM	0.1734 mL	0.8672 mL	1.7344 mL	8.6721 mL
20 mM	0.0867 mL	0.4336 mL	0.8672 mL	4.3361 mL
50 mM	0.0347 mL	0.1734 mL	0.3469 mL	1.7344 mL

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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