Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TCS 21311 (NIBR3049) is an effective and highly selective inhibitor of JAK3 (IC50: 8 nM). TCS 21311 inhibits PKCα, PKCθ, and GSK3β (IC50s: 13, 68, and 3 nM, respectively). It displays <100-fold selectivity over JAK1, JAK2, and TYK2.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 99.00 |
Description | TCS 21311 (NIBR3049) is an effective and highly selective inhibitor of JAK3 (IC50: 8 nM). TCS 21311 inhibits PKCα, PKCθ, and GSK3β (IC50s: 13, 68, and 3 nM, respectively). It displays >100-fold selectivity over JAK1, JAK2, and TYK2. |
Targets&IC50 | JAK2:2.55 μM, PKCα:13 nM, JAK1:1.017 μM, PKCθ:68 nM, JAK3:8 nM, GSK-3β:3 nM |
In vitro | TCS 21311 displays moderate activity in this cellular assay (IC50=689 nM, Jurkat cells), which is in good agreement with its enzymatic Pkc activity. TCS 21311 shows IC50 values of 1.017, 2.550, and 8.055 μM for JAK1, JAK2, and TYK2, respectively?in an enzymatic Jak assay [1]. |
Synonyms | NIBR3049 |
Molecular Weight | 526.51 |
Formula | C27H25F3N4O4 |
CAS No. | 1260181-14-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TCS 21311 1260181-14-3 Angiogenesis Chromatin/Epigenetic Cytoskeletal Signaling JAK/STAT signaling PI3K/Akt/mTOR signaling Stem Cells GSK-3 JAK PKC Protein kinase C Glycogen synthase kinase 3 TCS21311 Glycogen synthase kinase-3 Inhibitor TCS-21311 inhibit NIBR-3049 NIBR3049 Janus kinase NIBR 3049 inhibitor