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TCS-PIM-1-4a

Catalog No. T4215 CAS 327033-36-3

Synonyms: SMI-4a

TCS-PIM-1-4a (SMI-4a), a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).

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TCS-PIM-1-4a, CAS 327033-36-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 70.00
25 mg	In stock	$ 126.00
50 mg	In stock	$ 226.00
100 mg	In stock	$ 339.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.89%

Biological Description

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Storage & Solubility Information

Description	TCS-PIM-1-4a (SMI-4a), a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).
Targets&IC50	Pim:0.8-40 μM
In vitro	One hour inhibitor treatment (0.5 μM) of HEK-293T cultures at the end of a 4 hour 32PO4 incubation period results in nearly complete inhibition of the autophosphorylation of overexpressed Pim-1. Comparing to Inhibitor VI (Cat. No. 526524), Inhibitor V is less reactive towards DYRK1α (20% vs. 68% inhibition with respective inhibitor at 5 μM) and more potent in PC3 human prostate cancer cell killing (IC50 = 17 vs. 48 μM with respective inhibitor).

Synonyms	SMI-4a
Molecular Weight	273.23
Formula	C11H6F3NO2S
CAS No.	327033-36-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (201.3 mM)

References and Literature

1. Lin YW, et al. A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood. 2010 ;115(4):824-33. 2. Beharry Z, et al. The Pim protein kinases regulate energy metabolism and cell growth. Proc Natl Acad Sci U S A. 2011;108(2):528-33. 3. Benoit SR, Ji M, Fleming R,et al . Predictors of dropouts from a San Diego diabetes program: a case control study. Prev Chronic Dis. 2004:1(4):A10. 4. Xia Z, et al. Synthesis and Evaluation of Novel Inhibitors of Pim-1 and Pim-2 Protein Kinases. J. Med. Chem., 2009, 52 (1), pp 74-86

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Fluorochemical Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library Epigenetics Compound Library Reprogramming Compound Library Anti-Pancreatic Cancer Compound Library Bioactive Compound Library Kinase Inhibitor Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TCS-PIM-1-4a 327033-36-3 Apoptosis Chromatin/Epigenetic JAK/STAT signaling Pim arrest Bak Leukemic 4E-BP1 mTORC1 TCSPIM14a Pim kinases TCS PIM 1 4a Inhibitor p27Kip1 cell-cycle inhibit Bax SMI-4a inhibitor

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